Dr. Jerome Fortin
Academic title(s):
Assistant Professor, Department of Neurology and Neurosurgery
Associate Member, Department of Medicine, Division of Experimental Medicine
Link(s):
Current research:
We are interested in understanding how brain tumors arise, progress, and could be treated. We generate in vivo and in vitro disease models that carry glioma-causing mutations seen in human tumors. With these models, we dissect how mutations individually and cooperatively alter cell differentiation, proliferation, epigenetics, and metabolism. We use functional genomics (e.g. CRISPR/Cas9 gene editing) together with pharmacological tools to identify and characterize therapeutic targets.
Projects:
- Identification and characterization of therapeutic targets in IDH-mutant gliomas.
- Control of tumor cell fitness by epigenetic regulators in pediatric high-grade gliomas.
- Effects of sub-clonal mutations on the response of diffuse gliomas to therapy.
Selected publications:
Research areas:
Bioinformatics
Cancer
Drug discovery/ Therapeutics