Event

Chemical Society Seminar: Roger Linington - Integrated Methods for Bioactive Natural Product Discovery

Tuesday, October 30, 2018 13:00to14:30

Maass Chemistry Building Room 10, 801 rue Sherbrooke Ouest, Montreal, QC, H3A 0B8, CA

Although natural products have traditionally played an important role in therapeutic discovery and development, rediscovery of known compound classes is increasingly hampering novel compound development. ¹ To address this issue, our laboratory is developing new methods for the direct mechanistic and chemical characterization of small molecules in complex mixtures. ² Using a combination of multi-parametric high-throughput screening assays that report on compound modes of action, and untargeted metabolomics methods that describe the chemical complexity of natural products samples, we are creating pipelines for novel bioactive compound discovery. ³ These methods employ statistical methods to relate the presence or absence of compounds and compound classes to the presence or absence of specific phenotypes on screening libraries, providing a mechanism for the direct chemical and phenotypic profiling for all bioactive constituents from any natural products mixture. Recent results from this new platform will be presented.

(1) Pye, C. R.; Bertin, M. J.; Lokey, R. S.; Gerwick, W. H.; Linington, R. G. Proc. Natl. Acad. Sci. U.S.A. 2017, 114 (22), 5601.

(2) Ochoa, J. L.; Sanchez, L. M.; Koo, B.-M.; Doherty, J. S.; Rajendram, M.; Huang, K. C.; Gross, C. A.; Linington, R. G. ACS Infect. Dis. 2018, 4 (1), 59.

(3) Kurita, K. L.; Glassey, E.; Linington, R. G. P. Natl. Acad. Sci. U.S.A. 2015, 112 (39), 11999.

Roger Linington

He earned his B.Sc. in 1998 at the University of Leeds. In 2005 he earned his Ph.D at the University of British Columbia. Between 2005 - 2007 he was a Postdoctoral scholar at the University of California San Diego and the Smithsonian Tropical Research Institute. Between 2007-2012 Roger Linington was an Assistant Professor at the Department of Chemistry and Biochemistry at the University of California Santa Cruz. From 2012 until 2015, he was an Associate Professor in the Department of Chemistry and Biochemistry at the University of California Santa Cruz.