CCVC Seminar: Gregory Fu - Metal-Catalyzed Cross-Coupling Reactions of Alkyl Electrophiles
![](https://www.mcgill.ca/channels/files/channels/styles/fullwidth_breakpoints_theme_moriarty_small_1x/public/channels/image/fu.jpg?itok=6FAhVFkq)
Despite the tremendous accomplishments that have been described in the development of transition metal-catalyzed coupling processes, it is nevertheless true that many significant opportunities remain. For example, to date the overwhelming majority of studies have focused on couplings between two sp2-hybridized reaction sites (e.g., an aryl metal with an aryl halide).
As of 2001, there were relatively few examples of metal-catalyzed coupling reactions of alkyl electrophiles. During the past decade, we have pursued the discovery of transition metal-based catalysts for coupling activated and unactivated alkyl electrophiles that bear beta hydrogens. Our recent efforts to develop broadly applicable methods, including enantioselective processes, will be discussed.