Do adults with a history of childhood trauma have altered brain responses to psychological challenges? Previous studies indicated that this can occur in laboratory animals, but it has been unclear whether it occurs in humans.
The causes of psychiatric disorders are poorly understood. Now, in work led by researchers at McGill University, there is evidence that a wide range of early onset psychiatric problems (from depression, anxiety and addictions to dyslexia, bulimia, and ADHD) may be largely due to the combination of just three factors. The first is biological—in the form of individual variability in the brain’s dopamine reward pathway. The second is social—and points to the important role of early childhood neglect or abuse.
Even among non-dependent cocaine users, cues associated with consumption of the drug lead to dopamine release in an area of the brain thought to promote compulsive use, according to researchers at McGill University.
The findings, published in Scientific Reports, suggest that people who consider themselves recreational users could be further along the road to addiction than they might have realized.
It is our pleasure to announce a new Graduate Program Director, Dr. Naguib Mechawar!