Chemical Society Seminar: Cristina Nevado - Mechanistic Puzzles for Late Transition Metals

Zoom link: https://mcgill.zoom.us/j/81751403064?pwd=VER0K3pabjdQbG5sZEdJeFVFVm1ydz09

Abstract:

Our group has recently explored the reactivity of C and N centered radicals, in combination with transition metals, to streamline the functionalization of π-systems.

Nitrogen center radicals present divergent features: while highly reactive and thus difficult to control, they can also offer an excellent platform towards the formation not only of C-N but also remote C-C bonds. Here, we will present our efforts to generate and harvest these valuable intermediates in synthetically relevant contexts, including recent results towards their application in asymmetric transformations..^[1]

Further, examples of Nickel catalyzed dicarbofunctionalizations of alkenes and alkynes in a chemo-, regio- and stereoselective manner utilizing radicals as well as studies on the mechanistic features underlying these transformations will be presented in this lecture.^[2]

[1] C. Hervieu, M. Kirillova, T. Suárez, M. Müller, E. Merino, C. Nevado, Nat. Chem. 2021, 13, 327.

[2] a) S. Cuesta-Galisteo, J. Schörgenhumer, X. Wei, E. Merino, C. Nevado Angew. Chem. Int. Ed. 2021, 60, 1605; b) X. Wei, W. Shu, A. García-Domínguez, E. Merino, C. Nevado J. Am. Chem. Soc. 2020, 142, 13515.