Alan Barkun
Professor, Department of Medicine, McGill University; Associate Dept of Clinical Epidemiology and Biostatistics, cross-appt to Dept of Surgery, Mcgill University
MD,CM, FRCP(C), FACP, FACG, AGAF, MSc (Clinical Epidemiology and Biostatistics)
1988-1989 Clinical and Research Fellow in Hepatogastroenterology
Service du Professeur René Lambert, Hôpital Edouard Herriot
Faculty of Medicine, Claude Bernard University, Lyon, France
1989 Clinical and Research Fellow in Therapeutic Endoscopy and Gastroenterology
Duke University Medical Center, Durham, North Carolina, USA
1989 - Completion of core GI Fellowship, Division of Gastroenterology, McGill University
- Therapeutic Endoscopy
- GI bleeding
- Biliopancreatic
- Colorectal cancer screening
Alan Barkun is Director of Digestive Endoscopy, Chief Quality Officer, and director of the Therapeutic Endoscopy Third Tier Fellowship Training Program in the Division of Gastroenterology at McGill University and the McGill University Health Centre, Montréal, Canada. He is recipient of the DG Kinnear Chair in Gastroenterology at McGill University. Recipient of many national and international awards, Dr. Barkun has published over 400 peer-reviewed articles and abstracts, and has given over 600 international presentations on emerging digestive endoscopic technologies, with an emphasis on methodological, clinical and cost-effectiveness trials of treatments for upper gastrointestinal bleeding (UGIB), bilio-pancreatic diseases and colorectal cancer screening. He is also the current President of the colorectal Cancer screening implementation committee for the province of Quebec.
1: Barkun A, Bardou M. Proton-Pump Inhibitor Prophylaxis in the ICU - Benefits Worth the Risks? N Engl J Med. 2018 Dec 6;379(23):2263-2264. doi:
10.1056/NEJMe1810021. Epub 2018 Oct 24. PubMed PMID: 30354949.
2: Kherad O, Restellini S, Ménard C, Martel M, Barkun A. Implementation of a checklist before colonoscopy: a quality improvement initiative. Endoscopy. 2018
Mar;50(3):203-210. doi: 10.1055/s-0043-121218. Epub 2017 Dec 13. PubMed PMID:29237201.
3: Miller CS, Dorreen A, Martel M, Huynh T, Barkun AN. Risk of Gastrointestinal Bleeding in Patients Taking Non-Vitamin K Antagonist Oral Anticoagulants:
A Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2017 Nov;15(11):1674-1683.e3. doi: 10.1016/j.cgh.2017.04.031. Epub 2017 Apr 27.
Review. PubMed PMID: 28458008.
4: Almadi MA, Barkun A, Martel M. Plastic vs. Self-Expandable Metal Stents for Palliation in Malignant Biliary Obstruction: A Series of Meta-Analyses. Am J
Gastroenterol. 2017 Feb;112(2):260-273. doi: 10.1038/ajg.2016.512. Epub 2016 Nov 15. Review. PubMed PMID: 27845340.
5: Sharara N, Nolan S, Sewitch M, Martel M, Dias M, Barkun AN. Assessment of a Colonoscopy Triage Sheet for Use in a Province-Wide Population-Based Colorectal
Screening Program. Can J Gastroenterol Hepatol. 2016;2016:4712192. doi:10.1155/2016/4712192. Epub 2016 Jul 3. PubMed PMID: 27446841; PubMed Central
PMCID: PMC4947491.
6: Lu Y, Adam V, Teich V, Barkun A. Timing or Dosing of Intravenous Proton Pump Inhibitors in Acute Upper Gastrointestinal Bleeding Has Low Impact on Costs. Am J
Gastroenterol. 2016 Oct;111(10):1389-1398. doi: 10.1038/ajg.2016.157. Epub 2016 May 3. PubMed PMID: 27140030.
7: Chen YI, Barkun AN. Hemostatic Powders in Gastrointestinal Bleeding: A Systematic Review. Gastrointest Endosc Clin N Am. 2015 Jul;25(3):535-52. doi:
10.1016/j.giec.2015.02.008. Epub 2015 Apr 18. Review. PubMed PMID: 26142037.
8: Martel M, Barkun AN, Menard C, Restellini S, Kherad O, Vanasse A. Split-Dose Preparations Are Superior to Day-Before Bowel Cleansing Regimens: A
Meta-analysis. Gastroenterology. 2015 Jul;149(1):79-88. doi:10.1053/j.gastro.2015.04.004. Epub 2015 Apr 8. PubMed PMID: 25863216.
9: Laine L, Kaltenbach T, Barkun A, McQuaid KR, Subramanian V, Soetikno R; SCENIC Guideline Development Panel. SCENIC international consensus statement on
surveillance and management of dysplasia in inflammatory bowel disease. Gastroenterology. 2015 Mar;148(3):639-651.e28. doi: 10.1053/j.gastro.2015.01.031.
PubMed PMID: 25702852.
10: Lau JY, Barkun A, Fan DM, Kuipers EJ, Yang YS, Chan FK. Challenges in the management of acute peptic ulcer bleeding. Lancet. 2013 Jun 8;381(9882):2033-43.
doi: 10.1016/S0140-6736(13)60596-6. Review. PubMed PMID: 23746903.
11: Barkun AN, Adam V, Martel M, Bardou M. Cost-effectiveness analysis: stress ulcer bleeding prophylaxis with proton pump inhibitors, H2 receptor antagonists.
Value Health. 2013 Jan-Feb;16(1):14-22. doi: 10.1016/j.jval.2012.08.2213. PubMed PMID: 23337211.
12: Barkun AN, Bhat M, Armstrong D, Dawes M, Donner A, Enns R, Martin J, Moayyedi P, Romagnuolo J, Stitt L. Effectiveness of disseminating consensus management
recommendations for ulcer bleeding: a cluster randomized trial. CMAJ. 2013 Feb 19;185(3):E156-66. doi: 10.1503/cmaj.120095. Epub 2013 Jan 14. PubMed PMID:
23318399; PubMed Central PMCID: PMC3576461.
13: Almadi MA, Barkun AN, Martel M. No benefit of covered vs uncovered self-expandable metal stents in patients with malignant distal biliary
obstruction: a meta-analysis. Clin Gastroenterol Hepatol. 2013 Jan;11(1):27-37.e1. doi: 10.1016/j.cgh.2012.10.019. Epub 2012 Oct 23. PubMed
PMID: 23103324.
14: El Ouali S, Barkun AN, Wyse J, Romagnuolo J, Sung JJ, Gralnek IM, Bardou M, Martel M. Is routine second-look endoscopy effective after endoscopic hemostasis
in acute peptic ulcer bleeding? A meta-analysis. Gastrointest Endosc. 2012 Aug;76(2):283-92. doi: 10.1016/j.gie.2012.04.441. Epub 2012 Jun 12. PubMed PMID:
22695209.
15: Jones DJ, Barkun AN, Lu Y, Enns R, Sinclair P, Martel M, Gralnek I, Bardou M, Kuipers EJ, Sung J; International Consensus Upper Gastrointestinal Bleeding
Conference Group. Conflicts of interest ethics: silencing expertise in the development of international clinical practice guidelines. Ann Intern Med. 2012
Jun 5;156(11):809-16, W-283. doi: 10.7326/0003-4819-156-11-201206050-00008.
PubMed PMID: 22665816.
16: Almadi MA, Barkun JS, Barkun AN. Management of suspected stones in the common bile duct. CMAJ. 2012 May 15;184(8):884-92. doi: 10.1503/cmaj.110896. Epub 2012
Apr 16. Review. PubMed PMID: 22508980; PubMed Central PMCID: PMC3348191.
17: Armstrong D, Barkun A, Bridges R, Carter R, de Gara C, Dube C, Enns R, Hollingworth R, Macintosh D, Borgaonkar M, Forget S, Leontiadis G, Meddings J,
Cotton P, Kuipers EJ; Canadian Association of Gastroenterology Safety and Quality Indicators in Endoscopy Consensus Group. Canadian Association of Gastroenterology
consensus guidelines on safety and quality indicators in endoscopy. Can J Gastroenterol. 2012 Jan;26(1):17-31. PubMed PMID: 22308578; PubMed Central PMCID:
PMC3275402.
18: Barkun AN, Bardou M, Pham CQ, Martel M. Proton pump inhibitors vs. histamine 2 receptor antagonists for stress-related mucosal bleeding prophylaxis in
critically ill patients: a meta-analysis. Am J Gastroenterol. 2012 Apr;107(4):507-20; quiz 521. doi: 10.1038/ajg.2011.474. Epub 2012 Jan 31. PubMed
PMID: 22290403.
19: Almadi MA, Barkun A, Brophy J. Antiplatelet and anticoagulant therapy in patients with gastrointestinal bleeding: an 86-year-old woman with peptic ulcer
disease. JAMA. 2011 Dec 7;306(21):2367-74. doi: 10.1001/jama.2011.1653. Epub 2011 Nov 1. Erratum in: JAMA. 2012 Jan 11;307(2):147. PubMed PMID: 22045703.
20: Barkun AN, Bardou M, Kuipers EJ, Sung J, Hunt RH, Martel M, Sinclair P; International Consensus Upper Gastrointestinal Bleeding Conference Group.
International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med. 2010 Jan
19;152(2):101-13. doi: 10.7326/0003-4819-152-2-201001190-00009. PubMed PMID: 20083829.
21: Laine L, Spiegel B, Rostom A, Moayyedi P, Kuipers EJ, Bardou M, Sung J, Barkun AN. Methodology for randomized trials of patients with nonvariceal upper
gastrointestinal bleeding: recommendations from an international consensus conference. Am J Gastroenterol. 2010 Mar;105(3):540-50. doi:
10.1038/ajg.2009.702. Epub 2009 Dec 22. Review. PubMed PMID: 20029415.
22: Sung JJ, Barkun A, Kuipers EJ, Mössner J, Jensen DM, Stuart R, Lau JY, Ahlbom H, Kilhamn J, Lind T; Peptic Ulcer Bleed Study Group. Intravenous esomeprazole
for prevention of recurrent peptic ulcer bleeding: a randomized trial. Ann Intern Med. 2009 Apr 7;150(7):455-64. Epub 2009 Feb 16. PubMed PMID: 19221370.
23: Barkun AN, Martel M, Toubouti Y, Rahme E, Bardou M. Endoscopic hemostasis in peptic ulcer bleeding for patients with high-risk lesions: a series of
meta-analyses. Gastrointest Endosc. 2009 Apr;69(4):786-99. doi: 10.1016/j.gie.2008.05.031. Epub 2009 Jan 18. Review. PubMed PMID: 19152905.
24: Dial S, Kezouh A, Dascal A, Barkun A, Suissa S. Patterns of antibiotic use and risk of hospital admission because of Clostridium difficile infection. CMAJ.
2008 Oct 7;179(8):767-72. doi: 10.1503/cmaj.071812. PubMed PMID: 18838451; PubMed
Central PMCID: PMC2553880.
25: Al-Sabah S, Barkun AN, Herba K, Adam V, Fallone C, Mayrand S, Pomier-Layrargues G, Kennedy W, Bardou M. Cost-effectiveness of proton-pump
inhibition before endoscopy in upper gastrointestinal bleeding. Clin Gastroenterol Hepatol. 2008 Apr;6(4):418-25. doi: 10.1016/j.cgh.2007.12.037. Epub
2008 Mar 4. PubMed PMID: 18304891.
26: Barkun A. Maximizing the relationship with a mentor. Gastrointest Endosc. 2006 Dec;64(6 Suppl):S4-6. PubMed PMID: 17113853.
27: da Silveira EB, Lam E, Martel M, Bensoussan K, Barkun AN; RUGBE investigators. The importance of process issues as predictors of time to
endoscopy in patients with acute upper-GI bleeding using the RUGBE data. Gastrointest Endosc. 2006 Sep;64(3):299-309. PubMed PMID: 16923473.
28: Chan G, Barkun J, Barkun AN, Valois E, Cohen A, Friedman G, Parent J, Love J, Enns R, Baffis V, Jabbari M, Szego P, Stein L, Abraham N. The role of
ciprofloxacin in prolonging polyethylene biliary stent patency: a multicenter, double-blinded effectiveness study. J Gastrointest Surg. 2005 Apr;9(4):481-8.
PubMed PMID: 15797227.
29: Barkun A, Sabbah S, Enns R, Armstrong D, Gregor J, Fedorak RN, Rahme E, Toubouti Y, Martel M, Chiba N, Fallone CA; RUGBE Investigators. The Canadian Registry on Nonvariceal Upper Gastrointestinal Bleeding and Endoscopy (RUGBE):Endoscopic hemostasis and proton pump inhibition are associated with improvedoutcomes in a real-life setting. Am J Gastroenterol. 2004 Jul;99(7):1238-46.PubMed PMID: 15233660.
30: Barkun A, Bardou M, Marshall JK; Nonvariceal Upper GI Bleeding Consensus Conference Group. Consensus recommendations for managing patients with
nonvariceal upper gastrointestinal bleeding. Ann Intern Med. 2003 Nov 18;139(10):843-57. PubMed PMID: 14623622.
31: Romagnuolo J, Bardou M, Rahme E, Joseph L, Reinhold C, Barkun AN. Magnetic resonance cholangiopancreatography: a meta-analysis of test performance in suspected biliary disease. Ann Intern Med. 2003 Oct 7;139(7):547-57. PubMed PMID:14530225.
32: Makris N, Crott R, Fallone CA, Bardou M, Barkun A. Cost-effectiveness of routine endoscopic biopsies for Helicobacter pylori detection in patients with
non-ulcer dyspepsia. Gastrointest Endosc. 2003 Jul;58(1):14-22. PubMed PMID: 12838214.
33: Abraham N, Barkun A, Larocque M, Fallone C, Mayrand S, Baffis V, Cohen A, Daly D, Daoud H, Joseph L. Predicting which patients can undergo upper endoscopy
comfortably without conscious sedation. Gastrointest Endosc. 2002 Aug;56(2):180-9. PubMed PMID: 12145594.
34: Hunt RH, Barkun AN, Baron D, Bombardier C, Bursey FR, Marshall JR, Morgan DG, Paré P, Thomson AB, Whittaker JS. Recommendations for the appropriate use of
anti-inflammatory drugs in the era of the coxibs: defining the role of gastroprotective agents. Can J Gastroenterol. 2002 Apr;16(4):231-40. Review.
PubMed PMID: 11981576.
35: Barkun JS, Barkun AN, Sampalis JS, Fried G, Taylor B, Wexler MJ, Goresky CA, Meakins JL. Randomised controlled trial of laparoscopic versus mini
cholecystectomy. The McGill Gallstone Treatment Group. Lancet. 1992 Nov 7;340(8828):1116-9. PubMed PMID: 1359210.
36: Tse F, Barkun JS, Barkun AN. The elective evaluation of patients with suspected choledocholithiasis undergoing laparoscopic cholecystectomy.
Gastrointest Endosc. 2004 Sep;60(3):437-48. Review. PubMed PMID: 15332044.
37: Mehta SN, Pavone E, Barkun AN. Outpatient therapeutic ERCP: a series of 262 consecutive cases. Gastrointest Endosc. 1996 Oct;44(4):443-9. PMID: 8905366.
38: Barkun AN, Barkun JS, Fried GM, Ghitulescu G, Steinmetz O, Pham C, Meakins JL, Goresky CA. Useful predictors of bile duct stones in patients undergoing laparoscopiccholecystectomy. McGill Gallstone Treatment Group. Ann Surg. 1994 Jul;220(1):32-9. PMID:7517657.
39. Grover SA, Barkun AN, Sackett DL. The rational clinical examination. Does this patient have splenomegaly? JAMA. 1993 Nov 10;270(18):2218-21. No abstract available. Erratumin: JAMA. 2011 Apr 13;305(14):1414. PMID:8411607.
40. Barkun AN, Camus M, Green L, Meagher T, Coupal L, De Stempel J, Grover SA. The bedside assessment of splenic enlargement. Am J Med. 1991 Nov;91(5):512-8. PMID:1951414.