Profile
I was born in Buenos Aires, Argentina, and moved to Canada in 2004. In Vancouver, BC, I pursued my undergraduate studies in Biological Sciences at Simon Fraser University (SFU). At SFU, I obtained my first research experience under the supervision of Dr. Gordon Rintoul and developed a great interest in the field of neurophysiology while studying mitochondrial dynamics in neurons and astrocytes in the context of stroke. Later, I moved East to Montreal and joined Dr. Przemyslaw Sapieha ’s new laboratory at Maisonneuve-Rosemont Hospital to pursue graduate studies (M.Sc.) at the Department of Biochemistry and Molecular Medicine in the Université de Montréal. In Dr. Sapieha’s lab, I studied the interaction of neurons, vessels and the immune system in the pathophysiology of diabetic retinopathy and other retinal pathologies.
Following my master’s training, I worked at the Lady Davis Institute for Medical Research (Jewish General Hospital) in Dr. R. Aloyz ’s lab (Oncology, McGill), where we investigated the metabolic profile and rewiring of primary B-lymphocytes in chronic lymphocytic leukemia (CLL). By understanding CLL B-cell bioenergetics, we sought to co-opt their metabolic features to resensitize B-cells to already approved drugs via combination therapy with metabolism targeting drugs.
Through the study of the pathophysiology of stroke, several diabetic complications and leukemia, I became deeply interested in the epidemiological and clinical implications of these and other non-communicable chronic diseases.
As part of my doctoral training in Epidemiology at McGill University, I am currently applying and combining my experience in fundamental and translational research with genetic epidemiology in order to elucidate genetic determinants of several chronic diseases.
Academic training
Doctoral (Ph.D.) Student (Sep 2015 – Present)
Dept. of Epidemiology, Biostatistics and Occupational Health - McGill University, Montreal, Canada
Master of Science (M.Sc.) (Sep 2010 - Aug2013)
Dept. of Biochemistry and Molecular Medicine - University of Montreal (UdeM), Montreal, Canada
Dean of the Faculty of Medicine, Honours List
Bachelor of Science, Honours in Biology (Neurophysiology) (Sep 2004 - Apr 2009)
Dept. of Biological Sciences - Simon Fraser University, Vancouver, BC, Canada
Baccalaureate Specialized in Biological and Health Sciences (Mar 1998 - Dec 2003)
Colegio Nacional de Buenos Aires (University of Buenos Aires), Buenos Aires, Argentina
Publications
Miloudi, K., Binet, F., Wilson, A., Cerani, A., Oubaha, M., Menard, C., ... & Sapieha, P. (2016). Truncated netrin-1 contributes to pathological vascular permeability in diabetic retinopathy. The Journal of clinical investigation, 126(8), 3006-3022.
Dejda, A., Mawambo, G., Cerani, A., Miloudi, K., Shao, Z., Daudelin, J. F., ... & Sapieha, P. (2014). Neuropilin-1 mediates myeloid cell chemoattraction and influences retinal neuroimmune crosstalk. The Journal of clinical investigation, 124(11), 4807-4822. doi: 10.1172/JCI76492
Miloudi, K., Dejda, A., Binet, F., Lapalme, E., Cerani, A., & Sapieha, P. (2014). Assessment of vascular regeneration in the CNS using the mouse retina. JoVE (Journal of Visualized Experiments), (88), e51351-e51351. doi: 10.3791/51351
Cerani, A., Tetreault, N., Menard, C., Lapalme, E., Patel, C., Sitaras, N., ... & Sapieha, P. (2013). Neuron-derived semaphorin 3A is an early inducer of vascular permeability in diabetic retinopathy via neuropilin-1. Cell metabolism, 18(4), 505-518. doi: 10.1016/j.cmet.2013.09.003 Featured Article
Binet, F., Mawambo, G., Sitaras, N., Tetreault, N., Lapalme, E., Favret, S., ... & Juan, A. M. (2013). Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1α degradation of netrin-1. Cell metabolism, 17(3), 353-371. doi: 10.1016/j.cmet.2013.02.003
