Welcome to the MNI induced pluripotent stem cell (iPSC)/CRISPR Platform. To understand the work done at the MNI and within the platform, Dr. Durcan provides an overview in this video. He is also sharing his vision of the platform and standard operating protocols (SOPs) for working with iPSCs in his open lab notebook posts.

Established in 2015 with thanks to a private donation and funding from Brain Canada, the Montreal Neurological Institute (MNI) and the Quebec Parkinson’s Network; the MNI iPSC/CRISPR platform is part of a provincial partnership with the iPSC reprogramming platform at the Université of Laval. With expertise in neuronal differentiation and CRISPR genome editing, the platform strives to work with academic and industry users. As part of our services, we:

  • Help to train users on the use of iPSCs for their projects, through training workshops, in house training, and training manuals based on our SOPs( Made available starting in the Fall of 2018).
  • Liase with users interested in the development of new tools and technology that require the use of induced stem cells.
  • Work with users in the design and standardization of assays requiring the use of iPSC-derived neurons.
  • Translate in house and user-designed assays onto an automated high-content screening platform, for libraries of 5-8K compounds/small compounds. 

If interested in working with iPSCs for your research, feel free to contact thomas.durcan [at] mcgill.ca (Thomas Durcan) or lenore.beitel [at] mcgill.ca (Lenore Beitel) for any further information or to set up an initial meeting.