PhD Oral Defense: The M1AAP and M17LAP Aminopeptidases of Plasmodium falciparum Malaria
PhD Oral Defense of Rency Tesy Mathew, Institute of Parasitology
The intra-erythrocytic stage of the human malaria parasite, Plasmodium falciparum, employs two metallo-aminopeptidases, termed PfM1AAP and PfM17LAP, in the terminal stages of hemoglobin digestion. Inhibitors of these enzymes exhibit anti-malarial activity and, hence, either one or both enzymes are potential anti-malarial drug targets.