Professor
Medical Physics Unit, McGill University
Other Appointments:
Professor, Department of Oncology
Professor, Experimental Medicine
Address: |
Cedars Cancer Centre, Medical Physics, DS1.7141 |
Telephone: |
514 934 1934 et 44161 |
E-mail: |
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Education: |
Ph.D |
Research focus: |
Radiobiology, Tumor Biology, Drug Delivery, Functional Imaging 1. Identification of factors predictive of clinical response to radiotherapy using cDNA micro-array and other technologies. 2. The use of biodegradable polymers as delivery systems for radio/ chemosensitizing drugs. Demonstration of the applicability of this system to the delivery of chemotherapeutic drugs and halogenated pyrimidines (BrdUrd, IrdUd). Intra-tumoral system for delivery of 125IUdR has been used successfully in the treatment of glioma in a pre-clinical model. 3. Measurement of Relative Biological Effectiveness of implanted 125I seeds with that of external beam (60Co) radiation. in a clinically relevant model. The experimental set up and methods of analysis are equally applicable to other radioactive sources of clinical interest. 4. Investigation of the application of FDG-PET imaging as a non-invasive tool for functional imaging of tumors. Using a A fluorescent analog of FDG studies are being done in normal and malignant cell lines. . Factors contributing to the intensity of the PET image are being correlated with tumor histology, metabolism and microenvironmental status (hypoxia and pH). |
Key publications: |
S. Lehnert, Y. Li, E. Bump, W. Riddoch, A. Chenite, M. Shive, 125I-Iododeoxyuridine for the treatment of a brain tumor model: Selection of conditions for optimal effectiveness, Open Nuc. Med. J. 3, 19-24 (2011). S. Devic, N. Tomic, S. Faria, S. Menard, R. Lisbona, S. Lehnert, Defining radiotherapy target volumes using 18F-fluoro-deoxy-glucose positron emission tomography/ computed tomography: Still a Pandora’s box? Int. J. Radiat. Oncol. Biol. Phys. 78(5), 1555-62 (2010). S. Lehnert, B. Reniers, F. Verhagen, Relative biologic effectiveness in terms of tumor response of 125I implants compared with 60Co gamma rays, Int. J. Radiat. Oncol. Biol. Phys. 63, 224-229 (2005). Y. Li, A. Owusu, S. Lehnert, Treatment of intracranial rat glioma model with implant of radiosensitizer and biomodulator drug combined with external beam irradiation, Int. J. Radiat. Oncol. Biol. 58, 519-527 (2004). A. Doiron, D.T.T. Yapp, S. Lehnert, Tumor radiosensitization by sustained intra-tumoral release of bromodeoxyuridine, Cancer Res. 59, 3677-3681 (1999). G. Shenouda, S. Lehnert, B. Chehyab, D. Chehayab, I. Kaplan, A. Giaid. Inducible nitric oxide synthase and nitrotyrosinase in mice with radiation-induced lung damage, Am. J. Clin. Oncol. 26, e67-e72 (2003). |