Shirley Lehnert

Professor

Medical Physics Unit, McGill University

Other Appointments:

Professor, Department of Oncology

Professor, Experimental Medicine

Address:                           

Cedars Cancer Centre, Medical Physics, DS1.7141
McGill University Health Centre - Glen Site
1001 boul. Décarie
Montréal, QC H4A 3J1

Telephone:

514 934 1934 et 44161

E-mail:

Shirley.lehnert [at] mcgill.ca

Education:   

Ph.D

Research focus:

Radiobiology, Tumor Biology, Drug Delivery, Functional Imaging

1. Identification of factors predictive of clinical response to radiotherapy using cDNA  micro-array and other  technologies.  

2. The use of biodegradable polymers as delivery systems for radio/ chemosensitizing drugs.   Demonstration of  the applicability of this system to the delivery of  chemotherapeutic drugs   and halogenated pyrimidines (BrdUrd, IrdUd).   Intra-tumoral system  for delivery of 125IUdR  has been used successfully in the treatment of glioma in a pre-clinical model.

3.  Measurement of Relative Biological Effectiveness of implanted  125I seeds with that of external beam (60Co)  radiation. in a clinically relevant model. The experimental set up and methods of analysis are  equally applicable to other radioactive sources of clinical interest.

4. Investigation of the application  of FDG-PET imaging as a non-invasive tool for functional imaging of tumors. Using a A fluorescent analog of FDG   studies are being done in normal and malignant cell lines. .  Factors contributing to the intensity of the PET image  are being correlated with tumor histology, metabolism and microenvironmental  status (hypoxia and pH).

Key publications:

S. Lehnert, Y. Li, E. Bump, W. Riddoch, A. Chenite, M. Shive, 125I-Iododeoxyuridine for the treatment of a brain tumor model: Selection of conditions for optimal effectiveness, Open Nuc. Med. J. 3, 19-24 (2011).

S. Devic, N. Tomic, S. Faria, S. Menard, R. Lisbona, S. Lehnert, Defining radiotherapy target volumes using 18F-fluoro-deoxy-glucose positron emission tomography/ computed tomography: Still a Pandora’s box? Int. J. Radiat. Oncol. Biol. Phys. 78(5), 1555-62 (2010).

S. Lehnert, B. Reniers, F. Verhagen, Relative biologic effectiveness in terms of tumor response of 125I implants compared with 60Co gamma rays, Int. J. Radiat. Oncol. Biol. Phys. 63, 224-229 (2005).

Y. Li, A. Owusu, S. Lehnert, Treatment of intracranial rat glioma model with implant of radiosensitizer and biomodulator drug combined with external beam irradiation, Int. J. Radiat. Oncol. Biol. 58, 519-527 (2004).

A. Doiron, D.T.T. Yapp, S. Lehnert, Tumor radiosensitization by sustained intra-tumoral release of bromodeoxyuridine, Cancer Res. 59, 3677-3681 (1999).

G. Shenouda, S. Lehnert, B. Chehyab, D. Chehayab, I. Kaplan, A. Giaid. Inducible nitric oxide synthase and nitrotyrosinase in mice with radiation-induced lung damage, Am. J. Clin. Oncol. 26, e67-e72 (2003).