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UID:20240510T231605EDT-3224CvvO2T@132.216.177.157
DTSTAMP:20240511T031605Z
DESCRIPTION:\nGrâce à la générosité des fiducies Killam\, Le Neuro convoque
  lors d’une série de séminaires des conférenciers d’exception dont les tra
 vaux passionnent ses chercheurs et ceux de l’Université McGill. \n\n\nPour
  participer en personne\, inscrivez-vous ici\n\nPour visionner la diffusio
 n sur Vimeo\, cliquez sur le lien suivant\n\n\nJeehye Park\, PhD\n\nScient
 ifique principale\, Institut de recherche SickKids\, Professeure associée\
 , Département de génétique moléculaire\, Université de Toronto\, Canada\n
 \nHôte: gary.armstrong [at] mcgill.ca (Gary Armstrong)\n\nAbstract: Amyotr
 ophic lateral sclerosis (ALS) is a devastating neurodegenerative disease t
 hat leads to progressive decline in motor impairment\, muscle atrophy and 
 paralysis. ALS studies provided significant insights into the disease proc
 ess\, which may involve various molecular pathways and cellular dysfunctio
 n that contribute to neurodegeneration. However\, we still lack knowledge 
 of how ALS starts to occur and develop\, particularly the mechanism underl
 ying the early phase of the disease process. Understanding the early disea
 se stage rather than the late disease stage would enhance our chance of de
 veloping effective treatments that could stop or reverse the disease cours
 e. To identify the disease-initiating events leading to degeneration\, we 
 use our established ALS mouse model\, MATR3 S85C knock-in (KI) mice. A mis
 sense mutation S85C is the most frequently identified ALS-linked mutation 
 in MATR3\, which encodes an RNA binding protein involved in RNA splicing. 
 This newly established ALS model closely mimics the human disease genotype
  and phenotype\, offering enhanced disease relevance compared to existing 
 models in the ALS field and providing an unprecedented opportunity to stud
 y the early-stage development and progression of ALS. Using this mouse mod
 el\, we pursue to 1) determine the early disease events in the disease pro
 cess and 2) determine how the ALS-linked mutation alters MATR3 function an
 d properties to cause neurodegeneration. Our findings will uncover the ear
 ly disease process\, which may change the view of how ALS develop and prog
 ress. Defining the key early events will facilitate the development of ear
 ly prevention and intervention strategies for ALS.\n
DTSTART:20240611T200000Z
DTEND:20240611T210000Z
LOCATION:de Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Killam Seminar Series: Identifying the Early Events in ALS Pathogen
 esis in MATR3 S85C KI Mice
URL:https://www.mcgill.ca/neuro/fr/channels/event/killam-seminar-series-ide
 ntifying-early-events-als-pathogenesis-matr3-s85c-ki-mice-355311
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