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Douglas Arnold, MD

Contact Information

Email: douglas.arnold [at] (Douglas Arnold)
Tel: 514-398-8185
Recent Publications: GoogleScholar
Academic Affiliations: Neurology and Neurosurgery
Clinical Interests: MRI, MRS, Multiple Sclerosis, Neurological disorders
Research Groups: Neuroimaging and NeuroinformaticsNeuroimmunological Diseases


Dr. Douglas Arnold is a neurologist with special expertise in MRI. His personal research interests are centered on the use of advanced neuro-imaging techniques to assess the pathological evolution of multiple sclerosis and Alzheimer's disease and to quantify the effects of therapy on these diseases.

Selected Publications 

Lee H, Nakamura K, Narayanan S, Brown RA, Arnold DL, and Alzheimer's Disease Neuroimaging Initiative. Estimating and accounting for the effect of MRI scanner changes on longitudinal whole-brain volume change measurements. Neuroimage. [PMID: 30253207; Epub: 2018/09/22]

Hauser SL, Bar-Or A, Comi G, Giovannoni G, Hartung HP, Hemmer B, Lublin F, Montalban X, Rammohan KW, Selmaj K, Traboulsee A, Wolinsky JS, Arnold DL, Klingelschmitt G, Masterman D, Fontoura P, Belachew S, Chin P, Mairon N, Garren H, Kappos L, and OPERA I and OPERA II Clinical Investigators. Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis. N Engl J Med; 376(3): 221-234. [PMID: 28002679 ; F1000Prime: 727132301; Epub: 2016/12/21]

Brown RA, Narayanan S, and Arnold DL. Imaging of repeated episodes of demyelination and remyelination in multiple sclerosis. Neuroimage Clin; 6: 20-25. [PMID: 25610760; Epub: 2015/01/23]

Nakamura K, Guizard N, Fonov VS, Narayanan S, Collins DL, and Arnold DL. Jacobian integration method increases the statistical power to measure gray matter atrophy in multiple sclerosis. Neuroimage Clin; 4: 10-17. [PMID: 24266007; Epub: 2013/11/23]

Gold R, Kappos L, Arnold DL, Bar-Or A, Giovannoni G, Selmaj K, Tornatore C, Sweetser MT, Yang M, Sheikh SI, Dawson KT, and DEFINE Study Investigators. Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N Engl J Med; 367(12): 1098-1107. [PMID: 22992073; F1000Prime: 717965926; Epub: 2012/09/21]

Caramanos Z, Fonov VS, Francis SJ, Narayanan S, Pike GB, Collins DL, and Arnold DL. Gradient distortions in MRI: characterizing and correcting for their effects on SIENA-generated measures of brain volume change. Neuroimage; 49(2): 1601-1611. [PMID: 19682586; Epub: 2009/08/18]



The Montreal Neurological Institute & Hospital is a McGill University research and teaching institute; delivering the highest quality of care to patients, as part of the Neuroscience Mission of the McGill University Health Centre. The Neuro is proud to be a Killam Institution, supported by the Killam Trusts.