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Adrien Peyrache PhD

Contact Information

Email: adrien.peyrache [at] (Adrien Peyrache)
Tel.: 514-398-6780
Website: Peyrache Lab
Recent Publications: PubMed, Google Scholar 
Research GroupsNeural Circuits

Adrien Peyrache is studying the cognitive processes that humans use to navigate in their environment. Losing this ability is an early sign of Alzheimer’s disease.

Our thoughts, sensation, desires, emotions or, among others, ability to plan our life in the long run emerge from the collective activity of billions of neurons in the brain. Understanding the organization of neuronal activity in relation to behavior is the central questions in neuroscience as even slight modifications in the brain networks can lead to debilitating brain disorders. To address these questions, one needs a model. Peyrache and his colleagues focus their research at the lab on the neuronal basis of the brain's GPS in rodents as these animals are truly amazing at exploring their environments, avoiding dangerous spots and returning to their nest as quickly as needed.

Unraveling the relationship between cognitive processes and neuronal dynamics will take us one step further toward understanding the neural basis of cognitive impairments observed in disorders such as epilepsy and depression. In practice, the tools and expertise developed to answer the fundamental questions asked in the lab are used in collaborations with other teams to investigate how neuronal networks in the brain are affected in these diseases.

Selected Publications

Transformation of the head-direction signal into a spatial code. Peyrache A, Roux L, Schieferstein N, Buzsaki G. Nature Communications,  2017; 1752. 

Cholecystokinin Neurons of the Dentate Gyrus Initiate Behavioral Response to Antidepressants
Medrihan L, Sagi Y, Inde Z, Krupa O, Daniels C, Peyrache A and Greengard P. Neuron, 2017; 95, 564-576
Emergence of Cognition from Action. Buzsáki G, Peyrache A, Kubie J. Cold Spring Harb Symp Quant Biol., 2015

Internally-organized mechanisms of the head direction sense. Peyrache A, Lacroix M, Petersen P, Buzsaki G. Nature Neuroscience, 2015; 18(4):569-75.

Emergence of cognition from action. Buzsaki G, Peyrache A, Kubie J. Cold Spring Harb Symp Quant Biol. 2015;79:41-50.

Excitation and inhibition compete to control spiking during hippocampal ripples: intracellular study in behaving mice. English DF, Peyrache A, Stark E, Roux L, Vallentin D, Long MA, Buzsaki G. Journal of  Neuroscience 2014; 4(49):16509-17.

Spatio-temporal dynamics of neocortical excitation and inhibition during human sleep. Peyrache A, Dehghani N, Eskandar EN, Madsen JR, Anderson WS, Donoghue JA, Hochberg LR, Halgren E, Cash SS, Destexhe A. Proc Natl Acad Sci U S A 2012; 109(5):1731-6.

Inhibition recruitment in prefrontal cortex during sleep spindles and gating of hippocampal inputs. Peyrache A, Battaglia FP, Destexhe A. Proc Natl Acad Sci U S A 2011; 108(41):17207-12.

Coherent theta oscillations and reorganization of spike timing in the hippocampal-prefrontal network upon learning. Benchenane K, Peyrache A, Khamassi M, Battaglia FP, Wiener SI. Neuron, 2010.

Replay of rule-learning related neural patterns in the prefrontal cortex during sleep. Peyrache A, Khamassi M, Benchenane K, Wiener SI, Battaglia FP. Nature Neuroscience, 2009.

Principal component analysis of ensemble recordings reveals cell assemblies at high temporal resolution. Peyrache A, Benchenane K, Khamassi M, Wiener SI, Battaglia FP.
Journal of Computational Neuroscience, 2009

The Montreal Neurological Institute & Hospital is a McGill University research and teaching institute; delivering the highest quality of care to patients, as part of the Neuroscience Mission of the McGill University Health Centre. The Neuro is proud to be a Killam Institution, supported by the Killam Trusts.