Philippe Huot, MD, PhD

Email: philippe.huot [at] mcgill.ca (Dr. Philippe Huot )
Tel: 514-398-6125
Recent Publications: PubMed
Academic Affiliations: Neurology and Neurosurgery
Research Groups: Neurodegenerative Diseases

 


 

Dr. Philippe Huot uses experimental models of Parkinson’s disease (PD) to develop new drugs for the disease. “My laboratory focusses equally on discovering therapies to alleviate uncontrollable movements caused by PD and on looking for a total cure” says Dr. Huot, who trained in neurology at Université Laval and received his PhD from the University of Toronto, where he did post-doctoral research in movement disorders. After a term on the faculty of Université de Montréal, he joined The Neuro in May, 2017. “My experience at The Neuro has been extremely positive. It’s a dynamic environment that thrives on both basic science and clinical research. Everything is put in place so that researchers can focus on their work.”

His lab seeks to further the understanding of the neuro-chemistry and neuro-anatomy of the basal ganglia, a fascinating group of brain structures, under normal conditions as well as in Parkinson’s disease, a neuro-degenerative disease that affects as many as 1% of the population aged over 60. They are on a journey that will bring them closer to a cure to Parkinson’s disease. They also seek to discover drugs that will provide greater relief of parkinsonian disability and treatment-related complications, e.g. dyskinesia, motor fluctuations and visual hallucinations.

 

To this end, they use a wealth of in vivo approaches, including

  • Behavioural pharmacology in experimental models of Parkinson’s disease
  • Determination of the pharmacokinetic profile of investigational drugs in different pre-clinical models (LC-MS/MS)
  • Positron emission tomography (PET)
  • Magnetic resonance imaging (MRI)
  • Computed tomography (CT) scanning
  • Intra-cerebral stereotaxic delivery of substances

 

They will also use a breadth of post-mortem techniques, including

  • Auto-radiographic receptor/transporter binding in brain tissue
  • Western blotting
  • Immuno-histochemistry and stereological neuronal counting
  • In situ hybridisation

 

Funding:

The Weston Brain Institute
The Michael J Fox Foundation for Parkinson’s Research
Fonds de Recherche Québec – Santé
Natural Sciences and Engineering Research Council of Canada
Healthy Brains for Healthy Lives
Parkinson Canada

 

The Montreal Neurological Institute & Hospital is a McGill University research and teaching institute; delivering the highest quality of care to patients, as part of the Neuroscience Mission of the McGill University Health Centre. The Neuro is proud to be a Killam Institution, supported by the Killam Trusts.