Contact Information
Email: jean-paul.soucy [at] mcgill.ca (Jean-Paul Soucy)
Tel: 514-398-8515
Recent Publications: PubMed
Academic Affiliations: Neurology and Neurosurgery
Research Groups: Neuroimaging and Neuroinformatics, Epilepsy
Dr. Jean-Paul Soucy, MD, M.Sc., is Unit Director, Positron Emission Tomography. A physician whose primary training is in nuclear medicine, Dr. Soucy has expertise in the human applications of methods for the measurement of cerebral blood flow with SPECT, which he uses both clinically and in different research settings (including absolute quantification of cerebral blood flow). He has worked on approaches to quantify monoaminergic innervations in vitro with the goal of transferring these approaches to in vivo applications using PET. He is working on quantification of cholinergic systems using a PET ligand of the vesicular transporter for that transmitter. He is also involved in different projects applying signal enhancement techniques to nuclear-medicine-based neuroimaging. His research also extends to the PET evaluation of the proteinopathies associated with neurodegenerative conditions.
Selected Publications
Firoza Zubeida Lussier, Tharick Ali Pascoal, Mira Chamoun, Joseph Therriault, Cecile Tissot, Melissa Savard, Min Su Kang, Sulantha Mathotaarachchi, Andrea Lessa Benedet, Marlee Parsons, Muhammad Naveed Iqbal Qureshi, Emilie Thomas, Monica Shin, Laurie-Anne Dion, Gassan Massarweh, Jean-Paul Soucy, I-Huang Tsai, Paolo Vitali, Zahinoor Ismail, Pedro Rosa-Neto, Serge Gauthier. (2020). Mild behavioral impairment is associated with β-amyloid but not tau or neurodegeneration in cognitively intact elderly individuals. Alzheimer's & Dementia: The Journal of the Alzheimer's Association, DOI: 10.1002/alz.12007; 16: 192–199
Jake P. Levy, Melissa Savard, Tharick A. Pascoal, Elizabeth Finger, Jean-Paul Soucy, Pedro Rosa-Neto, and Simon Ducharme. (2020). Investigation of the Positron-Emission Tomography [18F]MK-6240 Tau Ligand in Genetic Frontotemporal Dementia. The Journal of Neuropsychiatry and Clinical Neurosciences, Accepted
Zukotynski K, Gaudet V, Kuo P, Adamo S, Goubran M, Scott C, Bocti C, Borrie M, Chertkow H, Frayne R, Hsiung R, Laforce R, Noseworthy MD, Prato FS, Sahlas JD, Smith EE, Sossi V, Thiel A, Soucy JP, Tardif JC, Black SE. (2020). The use of random forests to identify brain regions on amyloid and FDG PET associated with MoCA score. Clinical Nuclear Medicine, Accepted
Joseph Therriault, Andrea Benedet, Tharick Pascoal, Sulantha Mathotaarachchi, Mélissa Savard, Mira Chamoun, Emilie Thomas, Min Su (Peter) Kang, Firoza Lussier, Cecile Tissot, Jean-Paul Soucy, Gassan Massarweh, Soham Rej, Paramita Saha-Chaudhuri, Judes Poirier, Serge Gauthier, Pedro Rosa-Neto. (2020). APOEε4 potentiates the relationship between Amyloid-β and Tau pathologies. Molecular Psychiatry, accepted
Zahinoor Ismail, Sandra Black, Richard Camicioli, Howard Chertkow, Nathan Herrmann, Robert Laforce, Manuel Montero Odasso, Kenneth Rockwood ,Pedro Rosa-Neto, Dallas Seitz, Saskia Sivananthan, Eric E. Smith, Jean-Paul Soucy, Isabelle Vedel, Serge Gauthier. (2020). Recommendations of the 5th Canadian Consensus Conference on the Diagnosis and Treatment of Dementia. Alzheimer’s and Dementia, accepted
Manon Galoppin, Pierre Berroir, Jean-Paul Soucy, Yoshitaka Suzuki, Gilles J. Lavigne, Jean-François Gagnon, Paul Gravel, Jacques Y. Montplaisir, Emmanuel Stip, Pierre J. Blanchet. (2020). Chronic neuroleptic-induced parkinsonism examined with positron emission tomography. Movement Disorders, accepted
Thomas K Karikari, Tharick A Pascoal, Nicholas J Ashton, Shorena Janelidze, Andréa Lessa Benedet, Juan Lantero Rodriguez, Mira Chamoun, Melissa Savard, Min Su Kang, Joseph Therriault, Michael Schöll, Gassan Massarweh, Jean-Paul Soucy, Kina Höglund, Gunnar Brinkmalm, Niklas Mattsson, Sebastian Palmqvist, Serge Gauthier, Erik Stomrud, Henrik Zetterberg, Oskar Hansson†, Pedro Rosa-Neto†, Kaj Blennow. Blood phosphorylated tau 181 as a biomarker for Alzheimer’s disease: a modelling study using data from four prospective cohorts. (2020). The Lancet: Neurology 19, pp 422-433
Tharick A. Pascoal, Joseph Therriault, Sulantha Mathotaarachchi, Min Su Kang, Monica Shin, Andrea L. Benedet, Mira Chamoun, Cecile Tissot, Firoza Lussier, Sara Mohaddes, Jean-Paul Soucy, Gassan Massarweh, Serge Gauthier, and Pedro Rosa-Neto MD, for the Alzheimer’s Disease Neuroimaging Initiative. (2020). Topographical distribution of Aβ predicts progression to dementia in Aβ positive MCI. Alzheimers Dement (Amst) 2020 Jun 21;12(1):e12037. doi: 10.1002/dad2.12037
Andrée-Ann Baril, Jean-François Gagnon, Amélie Pelletier, Jean-Paul Soucy, Nadia Gosselin, Ronald B. Postuma, Jacques Montplaisir. (2020). Changes in regional cerebral perfusion over time in idiopathic REM sleep behavior disorder. Movement Disorders, http://dx.doi.org/10.1002/mds.28092
Tharick A. Pascoal, Joseph Therriault, Andrea L. Benedet, Melissa Savard, Firoza Z. Lussier, Mira Chamoun, Cécile Tissot, Muhammad Naveed Iqbal Qureshi, Min Su Kang, Sulantha Mathotaarachchi, Jenna Stevenson, Robert Hopewell, Gassan Massarweh, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Neto. (2020). 18F-MK-6240 PET for early and late detection of neurofibrillary tangles. Brain, DOI: 10.1093/brain/awaa180
Pedro Rosa-Neto, Min Su (Peter) Kang, Arturo Aliaga Aliaga, Monica Shin, Sulantha Mathotaarachchi, Andrea Benedet, Tharick Pascoal, Joseph Therriault, Mira Chamoun, Mélissa Savard, Gabriel Devenyi, Axel Mathieu, Mallar Chakravarty, Asa Sandelius, Kaj Blennow, Henrik Zetterberg, Jean-Paul Soucy, A. Claudio Cuello, Gassan Massarweh, Serge Gauthier. (2020). Amyloid modulates the association between neurofilament light chain and brain atrophy in Alzheimer’s disease. Molecular Psychiatry, accepted
Zacharie Saint-Georges, Synthia Guimond, Vanessa Zayed, Katie Dinelle, Clifford Cassidy, Jean-Paul Soucy, Gassan Massarweh, Benjamin Rotstein, Robert deKemp, Lauri Tuominen. (2020) First-in-Human Imaging and Kinetic Analysis of Vesicular Acetylcholine Transporter Density in the Heart Using [18F]FEOBV PET. Journal of Nuclear Cardiology, doi:10.1007/s12350-020-02323-w
Joseph Therriault, Tharick Pascoal, Melissa Savard, Andrea Benedet, Mira Chamoun, Cecile Tissot, Firoza Lussier, Min Su Kang, Emilie Thomas, Tatsuhiro Terada, Soham Rej, Gassan Massarweh, Ziad Nasreddine, Paolo Vitali, Jean-Paul Soucy, Paramita Saha-Chaudhuri, Serge Gauthier, and Pedro Rosa-Neto. (2020). Topographical distribution of amyloid-β, tau and atrophy in behavioral / dysexecutive AD patients. Neurology, accepted
David Bergeron, Jean-Mathieu Beauregard, Jean-Guimond, Jean-Paul Soucy, Louis Verret, Stéphane Poulin, Jordi A. Matias-Guiu, María Nieves Cabrera-Martín, Rémi W. Bouchard, Robert Laforce Jr. (2020). Posterior cingulate cortex hypometabolism in non-amnestic variants of Alzheimer’s disease. Journal of Alzheimer Disease, accepted
Mélanie Brisson; Catherine Brodeur; Laurent Létourneau-Guillon; Mario Masellis; Jon Stoessl; Alex Tamm; Katherine Zukotynski; Zahinoor Ismail; Serge Gauthier; Pedro Rosa-Neto, Jean-Paul Soucy. (2020) Clinical role of neuroimaging and liquid biomarkers in patients with cognitive impairment. Alzheimer's & Dementia: Translational Research & Clinical Interventions, accepted
Therriault J, Benedet A, Pascoal TA, Savard M, Ashton N, Chamoun M, Tissot C, Lussier F, Kang MSP, Bezgin G, Wang T, Fernandez-Arias J, Massarweh G, Vitali P, Zetterberg H, Blennow K, Saha-Chaudhuri P, Soucy JP, Gauthier S, Rosa-Neto P. Determining Amyloid-β positivity using [18F]AZD4694 PET imaging. J Nucl Med. 2020 Jul 31:jnumed.120.245209. doi: 10.2967/jnumed.120.245209
