Raymond 3-045 Friday 11:30 am
Macdonald Campus, McGill University

January 18th, 2019

Oçun Harçariz (yearly seminar) Institute of Parasitology

Elucidation of host-microbiome interactions in Caenorhabditis elegans

The native microbiome of Caenorhabditis elegans has recently been described. However, the interaction between these bacteria and the worm remains unknown. We analysed the bacterial effects on C. elegans against nanotoxicity. Two bacteria individually induce the worm to better deal with the toxicity, as compared to the other bacteria, in terms of progeny. We then carried out a comprehensive RNAseq analysis to understand the host-bacteria interaction in these worm phenotypes. Results will be discussed.

Jennifer Noonan (yearly seminar) Institute of Parasitology

Filarial pLGIC subunit functional change

Movement is mediated by neurotransmitter binding to pLGIC receptors. The function of heteromeric receptors, composed of different subunits, is governed by their composition and organization but it is not clear how this is determined. My PhD aims to identify residues critical for assembly and organization of subunits by analysis of gene duplication and their subsequent evolution. Gene duplications give rise to multiple copies of subunits allowing for evolutionary pressures to functionally change the subunits thereby fine tuning the receptor ligand-binding response. The mechanisms by which evolutionary pressures change a subunit post-duplication is unknown. The current objective is to describe this process while focusing on the duplication of filarial subunits unc-38 and unc-63.