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UID:20240419T014828EDT-3868UmKvOh@132.216.177.157
DTSTAMP:20240419T054828Z
DESCRIPTION:The normal heartbeat is conditioned by transient increases in t
 he intracellular free Ca2+ concentration. Ca2+ influx in cardiomyocytes is
  regulated by the activity of the heteromeric L-type voltage-activated CaV
 1.2 channel. A complex network of interactions between the different prote
 ins forming the ion channel determines the total Ca2+ influx. Alterations 
 in the biophysical and biochemical properties or in the biogenesis in any 
 of these proteins can lead to serious disturbances in the cardiac rhythm. 
 We have investigated the multi-subunit nature of the channel complex by ho
 mology with the three-dimensional structure of the closely related CaV1.1 
 channel. The architectural map identifies precise interaction loci between
  the different subunits and paves the way for elucidating the mechanistic 
 basis for the regulation of Ca2+ balance in cardiac myocytes under physiol
 ogical and pathological conditions. \n
DTSTART:20200221T160000Z
DTEND:20200221T170000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Seminar - Regulation of calcium channel activity in cardiomyocytes 
 : what is the role of auxiliary subunits?
URL:https://www.mcgill.ca/physiology/channels/event/seminar-regulation-calc
 ium-channel-activity-cardiomyocytes-what-role-auxiliary-subunits-300094
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