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UID:20240423T024807EDT-4012TmzV7a@132.216.177.157
DTSTAMP:20240423T064807Z
DESCRIPTION:In the developing nervous system\, an enormous number and diver
 sity of neurons are precisely organized into neural circuits. How can such
  a vast set of neural connections be wired using limited cues encoded in o
 ur genomes? To tackle this problem\, we are studying a family of neuronal 
 receptors with an extraordinary potential for conferring cell-surface dive
 rsity and wiring specificity. The clustered Protocadherin genes (Pcdhs) ar
 e tandemly arrayed on a single genomic locus and encode ~60 cadherin-relat
 ed transmembrane proteins that are combinatorially expressed among single 
 neurons. We propose that the Pcdhs serve as a code for ‘neuron individuali
 ty’ to mediate complex patterns of connectivity. I will discuss our recent
  work on the roles of Pcdhs in regulating the survival and integration of 
 GABAergic inhibitory interneurons during circuit development throughout th
 e brain. These studies will yield new insights on the cell-cell interactio
 ns and molecular cues that establish the proper balance and wiring of inhi
 bitory cells into circuits. I will also present work on cellular mechanism
 s that shape the morphologies of interneurons.\n\nThe MacIntosh Lectureshi
 p supports special seminars in honor of Dr. F.C. MacIntosh.\n
DTSTART:20200207T160000Z
DTEND:20200207T170000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Seminar - Molecular and cellular strategies for the patterning of n
 eurons into circuits
URL:https://www.mcgill.ca/physiology/channels/event/seminar-molecular-and-c
 ellular-strategies-patterning-neurons-circuits-300426
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