BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.177.157//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20240502T202406EDT-1652Ap77p0@132.216.177.157 DTSTAMP:20240503T002406Z DESCRIPTION:“Population Neuroimaging”\n\nThomas Nichols\, Oxford University \n Tuesday January 21\, 12-1pm\n Montreal Neurological Institute\, Jeanne Ti mmins Amphitheatre\n\nAbstract: Brain imaging studies have traditionally s truggled to break into 3-digit sample sizes: e.g.\, a recent Functional Ma gnetic Resonance Imaging (fMRI) meta-analysis of emotion found a median sa mple size of n=13. However\, we now have a growing collection studies with sample sizes with 4-\, 5- and even 6-digits. Many of these 'population ne uroimaging' studies are epidemiological in nature\, trying to characterise typical variation in the population to help predict health outcomes acros s the life span.\n\nI will discuss some of the challenges these studies pr esent\, in terms of massive computational burden but also in ways that the y expose shortcomings of existing mass univariate techniques. I will also discuss how these datasets present intriguing methodological problems here tofore absent from neuroimaging statistics. For example\, the 'null hypoth esis fallacy' is how H0 is never strictly true\, and yet with 100\,000 sub jects you'll eventually find some effect even if it is meaningless. This m otivates work spatial confidence sets on meaningful effect sizes (instead of thresholding test statistic images)\, providing intuitive measures of s patial uncertainty.\n DTSTART:20200121T170000Z DTEND:20200121T180000Z LOCATION:Jeanne Timmins Amphitheatre\, Montreal Neurological Institute\, CA \, QC\, Montreal\, H3A 2B4\, 3801 rue University SUMMARY:QLS Seminar - Thomas Nichols URL:https://www.mcgill.ca/qls/channels/event/qls-seminar-thomas-nichols-303 941 END:VEVENT END:VCALENDAR