Nuclear receptor-dependent insulin regulation of hepatic metabolism - BIOC 396 Undergraduate Research Project Application Form - Summer 2019

INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").

INSTRUCTIONS - STUDENTS: You may receive this form as a plain-text email, or you may consult this webpage. Print either one. Review and complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature"). Ask your supervisor to sign her/his section near the bottom. To request departmental permission to register, provide the signed form to the contact person corresponding to the course number below; this may or may not be your own department. Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.

INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either internal mail or PDF scan + email).

QUESTIONS? Please check the FAQs first. You will also find contact information for the Office for Undergraduate Research in Science on that page.


Supervisor's Name: Vincent Giguère

Supervisor's Email: vincent.giguere [at]

Supervisor's Phone: 5143985899

Supervisor's Website:

Supervisor's department: Biochemistry

Course number: BIOC 396 (Biochemistry)

Term: Summer 2019

Project start date: May 7 2019

Project end date: August 2 2019

Project title: Nuclear receptor-dependent insulin regulation of hepatic metabolism

Project description (50-100 words suggested): ERRα is a nuclear receptor that plays a crucial role in the control of energy metabolism. Previous study shows that ERRα inverse agonist improve insulin sensitivity. This makes ERRα a highly appealing therapeutic target to manage diabetes. However, a comprehensive understanding of the mechanism of action of ERRα in the liver is still lacking, and better knowledge of how ERRα activity is intertwined with and regulated by nutrients and hormone signaling is necessary. The project is to identify novel protein kinase/E3 ligase complexes regulating energy metabolism via ERRα, opening therapeutic avenues (e.g. kinase inhibitors) to treat metabolic diseases.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher + permission of instructor. All OK.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on laboratory performance as evaluated by the research supervisor (40%) and the final written research report (minimum 10 pages) graded by the supervisor and the course coordinator or the coordinator's delegate (60%).

Project status: This project is taken; however students may contact the professor to discuss other possible '396' projects this term.

How students can apply / Next steps: Bring a printed copy of this application form and your advising transcript to me during office hours.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Animal subjects; Biohazardous substances.

Student's Name:

Student's McGill ID:

Student's McGill Email:

Student's Phone:

Student's Program:

Student's Level (U0 / U1 / U2 / U3):

Student's signature - I certify that this course is with a different supervisor and on a different topic than any previous '396' course I have taken. I have not applied for another '396' course in this term:

Supervisor's signature - I give my permission for the student identified above to register for this project under my supervision:


After all parts of this application form are completed, and the hard copy is signed by the professor and the student, bring this application form and your unofficial transcript to the office or person listed at . Do not register for a '396' course on Minerva until you receive departmental permission.

Unit chair/director/designate's name:

Unit chair/director/designate's signature - I certify that this project conforms to departmental requirements for 396 courses: