INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").
INSTRUCTIONS - STUDENTS: You may receive this form as a plain-text email, or you may consult this webpage. Print either one. Review and complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature"). Ask your supervisor to sign her/his section near the bottom. To request departmental permission to register, provide the signed form to the contact person corresponding to the course number below; this may or may not be your own department. Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.
INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and send a copy of this form (with signatures) to the Office for Undergraduate Research in Science (either internal mail or PDF scan + email).
QUESTIONS? Please check the FAQs first. You will also find contact information for the Office for Undergraduate Research in Science on that page.
Supervisor's Name: Pia Wintermark
Supervisor's Email: pia.wintermark [at] mcgill.ca
Supervisor's Phone: 514-412-4452
Supervisor's Website: www.neobrainlab.org
Supervisor's department: Pediatrics
Course number: NSCI 396 (Neuroscience)
Term: Summer 2019
Project start date: May 1st, 2019
Project end date: August 31, 2019
Project title: Are the horizontal and amacrine cells injured due to bronchopulmonary dysplasia (BPD)?
Project description (50-100 words suggested): Hyperoxia associated with mechanical ventilation, which causes BPD in premature infants, seems also one of the responsible mechanisms causing damages to the developing brain and retina in these patients. Therefore, we hypothesize that stem cell treatments given to repair this BPD, that has been shown to repair the premature lungs, might also have potential therapeutic effects to repair these brain and retinal injuries.
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Grading scheme (The final report must be worth at least 50% of final grade): 10% for the Proposal Abstract, 50% for the Final Written Report, 40% for Laboratory Performance
Other project information: The proposed project will allow the assigned student to develop skills in the field of neonatal neurology. The student will review pertinent literature on the research topic. She will get the necessary training to comply with McGill regulations on animal experimentation. She will learn about the animal model. Initially in collaboration with senior graduate students and other undergraduate students, she will learn immunohistochemistry and compare results between rats exposed or not to hyperoxia and treated or not with stem cells.
Additionally to the above tasks, the student will write an experimental report. If experimental data obtained warrants it, she will contribute to the writing of an abstract to be presented at a scientific meeting.
The objectives of the study will be to: 1) review pertinent literature on the research topic; 2) learn about the animal models: rats exposed to hyperoxia (BPD model); 3) learn how to perform immunohistochemistry, take pictures with microscope, and measure cell numbers; 4) perform the analysis, interpret the results and write the report.
Project status: This project is taken; however students may contact the professor to discuss other possible '396' projects this term.
How students can apply / Next steps: Bring a printed copy of this application form and your advising transcript to me during office hours.
Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Animal subjects.