Investigator, Lady Davis Institute for Medical Research
Assistant Professor, Department of Oncology, McGill University
Associate Member - Department of Medicine, Division of Experimental Medicine
Dr. Orthwein's reserach interests are on B-cell biology and malignancies and DNA damage/repair. His lab investigates the mechanisms by which B-cells diversify their genome to allow for a protective immunity. This process, called antibody diversification, rely on programmed DNA lesions, in particular DNA double-strand breaks. The main focus of his research program is to understand how genome stability is maintained in B-cells during antibody diversification to develop an effective immune response against pathogens but prevent the formation of B-cell cancers.