Signal Transduction

Akavia, Uri David

Akavia, Uri David, Assistant Professor
uri.david.akavia [at] 
My lab devises and applies algorithms in computational biology to cancer, combining them with experimental approaches to systematically identify viable drug targets in the context of cancer therapeutics. The combination of these approaches will provide a fundamental understanding of oncogenesis, currently focusing on Glioblastoma, Breast Cancer and leukemia.

Beauchemin, Nicole

Beauchemin, Nicole, Professor
nicole.beauchemin [at]
Studies on the functions of the mouse CEACAM1 proteins in various tissues, their association with intracytoplasmic proteins and their connection with signaling cascades using transgenic and knockout mouse models. Role of the CEACAM1 proteins in colon tumor development, progression and metastasis in genetic models. Role of the CEACAM1 proteins in angiogenesis in transgenic mice.

Gallouzi, Imed

Gallouzi, Imed, Professor
imed.gallouzi [at]
Our general research area is mRNA metabolism during the cell cycle and cell differentiation. We use the tools of molecular and cell biology to study problems in this field. The long-term research goals focus on understanding the cellular mechanisms involved in the regulation of mRNA half-lives and how they affect cell growth and differentiation.

Gehring, Kalle

Gehring, Kalle, Professor
kalle.gehring [at]
Structural biology and biophysics of proteins and nucleic acids. The laboratory’s main research interests are poly(A) binding protein, ubiquitin-associated proteins, proteins involved in membrane trafficking, and ER protein folding. The methods used are nuclear magnetic resonance spectroscopy, X-ray crystallography and small-angle X-ray scattering in combination with the techniques of molecular biology.

Guarne, Alba

Guarne, Alba, Professor
guarnea [at]
Our goal is to understand how proteins determine the fate of DNA during chromosome replication and repair. In particular, how regulatory proteins orchestrate the stabilization of damaged replication forks with DNA repair and forks restart. Since most of the proteins that regulate these processes lack a measurable enzymatic activity, our efforts are aimed at seeing how they work using a broad range of structural biology techniques. We then combine structural information with biochemical and genetic analysis to elucidate their functions at a molecular level.

Huang, Sidong

Huang, Sidong, Assistant Professor
sidong.huang [at]
Our laboratory uses functional genomic tools to study cancer-relevant pathways and to guide targeted cancer therapy. We aim to identify novel genes and networks that modulate response to cancer drugs, and to uncover genetic dependencies between the major signaling pathways in cancer that can be exploited therapeutically.

Kazak, Lawrence

Kazak, Lawrence, Assistant Professor
lawrence.kazak [at]
The Kazak lab combines mouse genetics, mass spectrometry, molecular and cell biology, biochemistry and bioenergetics to study the molecular control of mammalian energy metabolism. Our efforts are concentrated on the molecules and metabolic pathways that control mitochondrial energetics in adipocytes and cancer cells. We have generated novel genetically-engineered mouse models to accurately study cellular metabolism, in vivo. In the case of adipose tissue, we systematically examine mechanisms supporting adipocyte energy expenditure, which has tremendous promise for combating obesity. In the case of cancer, we are leveraging our expertise of mitochondrial biology and cellular energetics to explore novel metabolic pathways that are critical for tumorigenesis.

Muller, William

Muller, William, Professor
william.muller [at]
The progression of the primary mammary epithelial cell to malignant phenotype involves multiple genetic events including the activation of dominant activating oncogenes and inactivation of specific tumor suppressor genes. Our laboratory has focused on the role of a class of receptor tyrosine kinases known as the epidermal growth factor receptor (EGFR) family in the induction of breast cancer .Elevated expression of the various EGFR family members has been observed in a large proportion of sporadic breast cancers and their derived cell lines. For example, amplification and overexpression of erbB-2/neu proto-oncogene is observed in 20-30% human breast cancer and is inversely correlated with the survival of the patient. The major focus of our laboratory is to determine the relative contribution of the various EGFR family members and their coupled signaling pathways in ErbB-2 induced mammary tumor progression. Given the fact that germline inactivation of these signaling pathways results in either embryonic or perinatal lethality, we have used use Cre/Lox recombination system to specifically inactivate each of these signaling molecules members in the mammary epithelium of mice expressing activated erbB-2. The results of these biochemical and genetic analyses will provide important insight in molecular basis for erbB-2 induced tumorigenesis and metastasis.

Nagar, Bhushan

Nagar, Bhushan, Professor
bhushan.nagar [at]
X-ray crystallography, NMR, SAXS and biophysical characterization of proteins in cellular signal transduction pathways that control innate immunity, protein translation initiation and RNA interference with emphasis on molecular mechanisms of regulation. Structural information will be used to glean protein function and aid in the rational development of therapies against cancer and diseases associated with infection and autoimmunity.

Nepveu, Alain

Nepveu, Alain, Professor
alain.nepveu [at]
Transcriptional regulation in normal and cancer cells (expression profiling, genome-wide location arrays (ChIP-chip)). Post-translational regulation by cyclin-dependent kinases during cell cycle progression, and by checkpoint kinases following DNA damage. The spindle assembly checkpoint and the control of genomic instability. Spontaneous and induced point mutations. Transgenic mouse models of breast cancer: a model for the basal-like group of breast cancers and transcriptional regulation of the Wnt/beta-catenin pathway.

Park, Morag

Park, Morag, Professor
morag.park [at]

Deregulation of receptor tyrosine kinases is a common event in the development and progression of human cancers. We propose to examine the signals regulated by receptor tyrosine kinases that promote cell transformation, tumor formation and metastatic spread of tumors with a focus on breast cancer.

Pause, Arnim

Pause, Arnim, Professor
arnim.pause [at]
(1) Molecular characterization of the von Hippel-Lindau (VHL) tumor suppressor gene pathway, identification of new targets of the VHL ubiquitin ligase, mechanism of tumorigenesis in VHL tumors (renal cell carcinoma) and C.elegans, development of animal models of kidney cancer (mice and C.elegans). (2) Functional characterization of the Birt-Hogge-Dube (BHD) tumor suppressor protein in kidney cancer and in cellular and whole animal metabolism (mice and C.elegans). (3) Functional characterization of a tyrosine phosphatase involved in tumor suppression, studies in cellular and animal models.

Pelletier, Jerry

Pelletier, Jerry, Professor
jerry.pelletier [at]
Chemical Biology Approach to Study Regulation of Eukaryotic Translation — Chemical Biology Approach to Interdict miRNA—mediated Repression — Targeting Translation Initiation in Cancer as a Therapeutic Avenue — Use of Mechanism Based Mouse Models to Study Response to Chemotherapy — Biology of RNA Helicases.

Sonenberg, Nahum

Sonenberg, Nahum, Professor
nahum.sonenberg [at]

Control of translation in eukaryotes; translational control cancer, obesity and neurodegenerative diseases; translational control of learning and memory; ‘knock-out’ mice in translation initiation factors.

Teodoro, Jose

Teodoro, Jose, Associate Professor
jose.teodoro [at]
Projects in the lab identify and characterize pathways that target tumour growth. The first project studies how the p53 tumour suppressor pathway is able to inhibit angiogenesis. Angiogenesis is the process of blood vessel formation that is required for tumour formation. Molecular and proteomic approaches are used to identify p53-induced angiogenesis inhibitors and define how such factors work. The second project in the lab studies cytotoxic viral proteins and how such factors destroy cancer cells. A number of such viral proteins interact with and inhibit a protein complex called the Anaphase Promoting Complex/Cyclosome (APC/C). Work in the lab seeks to determine why the APC/C is a general target of many viruses and how inhibition of this complex can lead to specific destruction of cancer cells.

Thomas, David Y

Thomas, David Y., Professor
david.thomas [at]
There are two major projects in this group. Cell signaling pathways and molecular chaperone systems in the endoplasmic reticulum and their role in diseases. We use a variety of genetic, biochemical informatics and structural approaches to these problems.

Tremblay, Michel L

Tremblay, Michel L., Professor
michel.tremblay [at]
In vitro and in vivo characterization of protein tyrosine phosphatases in the mouse. Generation of PTPase mouse models using homologous recombination in embryonic stem cells and transgenic technology.

Watson, Ian

Watson, Ian, Assistant Professor
ian.watson2 [at]

My lab is interested in understanding the biological function and therapeutic relevance of novel significantly mutated genes discovered in our melanoma genome- and exome-sequencing studies by employing computational approaches, in vivo models and biochemical techniques studying patient samples, cell lines and genetically engineered mice.