Neuro Epilepsy Lecture Series - Red and Green Spikes Revisited: Is the Concept Still Valid?
The 2024-2025 Neuro Epilepsy Lecture Series will include eight lectures covering hot topics in basic and clinical epilepsy research. Speakers will include distinguished leaders and rising stars, with the goal of bridging basic research and clinical perspectives.
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Birgit Frauscher, PhD
Professor, Department of Neurology, Duke University School of Medicine
Host: Boris Bernhardt
Talk Title: Red and Green Spikes Revisited: Is the Concept Still Valid?
Abstract: Several decades ago, Penfield and Jasper introduced the concept of 'red' and 'green' spikes in epilepsy presurgical evaluation. This concept suggests that there are two distinct spike subtypes with different generation mechanisms and contrasting implications for clinical management. This talk will revisit this concept from various perspectives: it will review the latest evidence indicating that not all spikes are equal, with some subtypes being more critical for epileptogenicity than others. It will also discuss how spikes can be used to address the longstanding issue of limited sampling in invasive intracranial EEG. Finally, the talk will challenge the current paradigm that focuses primarily on the recording of seizures, highlighting how spikes and other seizure-independent biomarkers can indeed be valuable for epilepsy presurgical evaluation.
These seminar series are made possible through the sponsorship of:
