An anonymous reader quotes a report from Science Magazine: Authors of a landmark Alzheimer's disease research paper published in Nature in 2006 have agreed to retract the study in response to allegations of image manipulation. University of Minnesota (UMN) Twin Cities neuroscientist Karen Ashe, the paper's senior author, acknowledged in a post on the journal discussion site PubPeer that the paper contains doctored images. The study has been cited nearly 2500 times, and would be the most cited paper ever to be retracted, according to Retraction Watch data. "Although I had no knowledge of any image manipulations in the published paper until it was brought to my attention two years ago," Ashe wrote on PubPeer, "it is clear that several of the figures in Lesne et al. (2006) have been manipulated ... for which I as the senior and corresponding author take ultimate responsibility." After initially arguing the paper's problems could be addressed with a correction, Ashe said in another post last week that all of the authors had agreed to a retraction -- with the exception of its first author, UMN neuro-scientist Sylvain Lesne, a protege of Ashe's who was the focus of a 2022 investigation by Science. "It's unfortunate that it has taken 2 years to make the decision to retract," says Donna Wilcock, an Indiana University neuroscientist and editor of the journal Alzheimer's & Dementia. "The evidence of manipulation was overwhelming." The 2006 paper suggested an amyloid beta (AB) protein called AB*56 could cause Alzheimer's. AB proteins have long been linked to the disease. The authors reported that AB*56 was present in mice genetically engineered to develop an Alzheimer's-like condition, and that it built up in step with their cognitive decline. The team also reported memory deficits in rats injected with AB*56. For years researchers had tried to improve Alzheimer's outcomes by stripping amyloid proteins from the brain, but the experimental drugs all failed. AB*56 seemed to offer a more specific and promising therapeutic target, and many embraced the finding. Funding for related work rose sharply. But the Science investigation revealed evidence that the Nature paper and numerous others co-authored by Lesne, some listing Ashe as senior author, appeared to use manipulated data. After the story was published, leading scientists who had cited the paper to support their own experiments questioned whether AB*56 could be reliably detected and purified as described by Lesne and Ashe -- or even existed. Some said the problems in that paper and others supported fresh doubts about the dominant hypothesis that amyloid drives Alzheimer's. Others maintained that the hypothesis remains viable. That debate has continued amid the approval of the antiamyloid drug Leqembi, which modestly slows cognitive decline but carries risks of serious or even fatal brain swelling or bleeding.

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The Israeli military said it killed militants in the central part of the enclave on Friday, a day after a strike on a former school, where Gazan officials say civilians were killed.

During the cross-examination, government lawyers elicited anguished, and excruciating, details about their relationship at the time.

Michelle Lewis reports via Electrek: The world's largest solar farm, in the desert in northwestern Xinjiang, is now connected to China's grid. The 3.5-gigawatt (GW), 33,000-acre solar farm is outside Urumqi, Xinjiang's capital. The state asset regulator's website cited the Power Construction Corp of China and said it came online on Monday. The solar farm will generate about 6.09 billion kilowatt hours (kWh) of electricity annually. Assuming an EV consumes about 3,000 kWh per year, 6.09 billion kWh could power 2.03 million EVs annually. The world's largest solar farm in Xinjiang is part of China's megabase project, a plan to install 455 GW of wind and solar. The megabase projects are sited in sparsely populated, resource-rich areas and send their generated energy to major urban centers, such as on China's eastern seaboard. China now boasts the three largest solar farms in the world by capacity. The Ningxia Tenggeli and Golmud Wutumeiren solar farms, each with a capacity of 3 MW, are already online.

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The host thanked the show’s viewers and had special words for his co-star, Vanna White, before he signed off for the final time.

As reported by Jon Peddie Research, Nvidia now holds 88% of the GPU market after its market share jumped 8% in its most recent quarter. "This jump shaves 7% off of AMD's share, putting it down to 19% total," reports XDA Developers. "And if you're wondering where that extra 1% went, it came from all of Intel's market share, squashing it down to 0%." From the report: Dr. Jon Peddie, president of Jon Peddie Research, mentions how the GPU market hasn't really looked "normal" since the 2007 recession. Ever since then, everything from the crypto boom to COVID has messed with the usual patterns. Usually, the first quarter of a year shows a bit of a dip in GPU sales, but because of AI's influence, it may seem like that previous norm may be forever gone: "Therefore, one would expect Q2'24, a traditional quarter, to also be down. But, all the vendors are predicting a growth quarter, mostly driven by AI training systems in hyperscalers. Whereas AI trainers use a GPU, the demand for them can steal parts from the gaming segment. So, for Q2, we expect to see a flat to low gaming AIB result and another increase in AI trainer GPU shipments. The new normality is no normality."

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In a democracy, how far is too far?

Will Lewis, the chief executive, pledged to employees to “improve how well I listen,” while Matt Murray, the new editor, tried to reassure staff members.

The newspaper’s new publisher argued against coverage of British phone hacking. Instead, he has invited renewed scrutiny.

Bruce66423 shares a report from The Independent: A potential disaster was narrowly avoided when a packed passenger plane took off just seconds before it was about to run out of runway because of a software glitch. The Boeing aircraft, operated by TUI, departed from Bristol Airport for Las Palmas, Gran Canaria on 9 March with 163 passengers on board when it struggled to take off. The 737-800 plane cleared runway nine with just 260 metres (853ft) of tarmac to spare at a height of 10ft. It then flew over the nearby A38 road at a height of just 30 metres (100ft) travelling at the speed of around 150kts (about 173mph). The A38 is a major A-class busy road, connecting South West England with the Midlands and the north. The Air Accidents Investigation Branch (AAIB), part of the Department for Transport, said the incident was the result of insufficient thrust being used during take-off. Pilots manually set the thrust level following a software glitch that Beoing was aware of before take-off. "A Boeing 737-800 completed a takeoff from Runway 09 at Bristol Airport with insufficient thrust to meet regulated performance," the AAIB report said. "The autothrottle (A/T) disengaged when the takeoff mode was selected, at the start of the takeoff roll, and subsequently the thrust manually set by the crew (84.5% N1 ) was less than the required takeoff thrust (92.8% N1 ). Neither pilot then noticed that the thrust was set incorrectly, and it was not picked up through the standard operating procedures (SOPs)."

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They say their options are limited by the court’s status as a separate branch of government and deep Republican opposition.

An anonymous reader quotes a report from Time Magazine: Called "Tokyo Futari Story," the city hall's new initiative is just that: An effort to create couples, "futari," in a country where it is increasingly common to be "hitori," or alone. While a site offering counsel and general information for potential lovebirds is online, a dating app is also in development. City hall hopes to offer it later this year, accessible through phone or web, a city official said Thursday. Details were still undecided. City Hall declined to comment on Japanese media reports that said the app will require a confirmation of identity, such as a driver's license, your tax records to prove income and a signed form that says you are ready to get married. According to Health Ministry data released on Wednesday, Japan's birth rate fell to a new low for the eighth straight year in 2023. "According to the latest statistics, Japan's fertility rate -- the average number of babies a woman is expected to have in her lifetime -- stood at 1.2 last year," reports ABC News. "The 727,277 babies born in Japan in 2023 were down 5.6% from the previous year, the ministry said -- the lowest since Japan started compiling the statistics in 1899. Separately, the data shows that the number of marriages fell by 6% to 474,717 last year, something authorities say is a key reason for the declining birth rate."

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The women called to testify have at different times tried to support a man whose history of addiction continues to hit them with shrapnel.

Victoria Song reports via The Verge: Samsung Electronics workers went on a strike on Friday for the very first time in the company's history. The move comes at a time when the Korean corporation faces increased competition from other chipmakers, particularly as demand for AI chips grows. The National Samsung Electronics Union (NSEU), the largest of the company's several unions, called for the one-day strike at Samsung's Seoul office building as negotiations over pay bonuses and time off hit a standstill. The New York Times reports that the majority of striking workers come from Samsung's chip division. (Samsung Electronics is technically only a subsidiary comprising its consumer tech, appliances, and semiconductor divisions; Samsung itself is a conglomerate that controls real estate, retail, insurance, food production, hotels, and a whole lot more.) It's unclear how many of the NSEU's roughly 28,400 members participated in the walkout. Even so, multiple outlets are reporting that the walkout is unlikely to affect chip production or trigger shortages. Union leaders told Bloomberg that further actions are planned if management refuses to engage. That said, the fact that it's happening at all is awkward timing for Samsung, particularly due to tensions with the chipmaking portion of its business. Last year, the division reported a 15 trillion won ($11 billion) loss, leading to a 15-year low in operating profits. The current AI boom played a big role in the massive loss. Samsung has historically been the world leader in making high-bandwidth memory chips â" the kind that are in demand right now to power next-gen generative AI features. However, last year's decline was partly because Samsung wasn't prepared for increased demand, allowing local rival SK Hynix to take the top spot.

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The places on this year’s “50 Best” list are endurance tests, theatrical spectacles, monuments to ego and — the two most frightening words in dining — “immersive experiences.”

United Airlines on Friday launched a media platform to serve travelers personalized ads on seat-back screens and in its app, among other platforms, as it seeks to leverage customer data. CNBC reports: United said its new platform, Kinective Media, is already working with Norwegian Cruise Line, Macy's, IHG Hotels & Resorts, TelevisaUnivision and JPMorgan Chase, which offers a host of co-branded credit cards with United. [...] Customers can opt out of seeing targeted ads through a United web page, and United says advertisers can't access customers' personally identifiable information, the airline said. "There is the potential for 3.5 hours of attention per traveler, based on average flight time," United said.

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But money to the families would fall far short of the more than $1.4 billion they were awarded by juries for Mr. Jones’s lies about the 2012 school massacre.

An anonymous reader quotes a report from Ars Technica: After acquiring VMware, Broadcom swiftly enacted widespread changes that resulted in strong public backlash. A new survey of 300 director-level IT workers at companies that are customers of North American VMware provides insight into the customer reaction to Broadcom's overhaul. The survey released Thursday doesn't provide feedback from every VMware customer, but it's the first time we've seen responses from IT decision-makers working for companies paying for VMware products. It echos concerns expressed at the announcement of some of Broadcom's more controversial changes to VMware, like the end of perpetual licenses and growing costs. [...] Every person surveyed said that they expect VMware prices to rise under Broadcom. In a March "User Group Town Hall," attendees complained about "price rises of 500 and 600 percent," according to The Register. We heard in February from ServeTheHome that "smaller" cloud service providers were claiming to see costs grow tenfold. In this week's survey, 73 percent of respondents said they expect VMware prices to more than double. Twelve percent of respondents expect a price hike of 301 to 500 percent. Only 1 percent anticipate price hikes of 501 to 1,000 percent. "At this juncture post-acquisition, most larger enterprises seem to have a clear understanding of how their next procurement cycle with Broadcom will be impacted from a pricing and packaging standpoint," the report noted. Further, 95 percent of survey respondents said they view Broadcom buying VMware as disruptive to their IT strategy, with 46 percent considering it extremely or very disruptive. Widespread concerns about cost and IT strategy help explain why 99 percent of the 300 respondents said they are concerned about Broadcom owning VMware, with 46 percent being "very concerned" and 30 percent "extremely concerned." Despite widespread anxiety over Broadcom's VMware, most of the respondents said they will likely stay with VMware either partially (43 percent of respondents) or fully (40 percent). A smaller percentage of respondents said they would move more workloads to the public cloud (38 percent) or a different hypervisor (34 percent) or move entirely to the public cloud (33 percent). This is with 69 percent of respondents having at least one contract expiring with VMware within the next 12 months. [...] Top reasons cited for considering abandoning VMware partially or totally were uncertainty about Broadcom's plans, concerns about support quality under Broadcom, and changes to relationships with channel partners (each named by 36 percent of respondents). Following closely was the shift to subscription licensing (34 percent), expected price bumps (33 percent), and personal negative experiences with Broadcom (33 percent). Broadcom's history with big buys like Symantec and CA Technologies also has 32 percent of people surveyed considering leaving VMware. "The emotional shock has started to metabolize inside of the Broadcom customer base, but it's metabolized in the form of strong commitment to mitigating the negative impacts of the Broadcom VMware acquisition," said Kyle Campos, CTPO for CloudBolt Software, the company that commissioned the study. He warned that Broadcom could see backlash continue "for months and even years to come."

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Israel said it struck three classrooms used by 20 to 30 Palestinian militants. Gazan health authorities said that many women and children were among the dozens killed.

Hollywood actor and venture capitalist Ashton Kutcher believes that one day, entire movies will be made on AI tools like OpenAI's Sora. From a report: The actor was speaking at an event last week organized by the Los Angeles-based think tank Berggruen Institute, where he revealed that he'd been playing around with the ChatGPT maker's new video generation tool. "I have a beta version of it and it's pretty amazing," said Kutcher, whose VC firm Sound Venture's portfolio includes an investment in OpenAI. "You can generate any footage that you want. You can create good 10, 15-second videos that look very real." "It still makes mistakes. It still doesn't quite understand physics. But if you look at the generation of this that existed one year ago, as compared to Sora, it's leaps and bounds. In fact, there's footage in it that I would say you could easily use in a major motion picture or a television show," he continued. Kutcher said this would help lower the costs of making a film or television show. "Why would you go out and shoot an establishing shot of a house in a television show when you could just create the establishing shot for $100?" Kutcher said. "To go out and shoot it would cost you thousands of dollars," Kutcher was so bullish about AI advancements that he said he believed people would eventually make entire movies using tools like Sora. "You'll be able to render a whole movie. You'll just come up with an idea for a movie, then it will write the script, then you'll input the script into the video generator, and it will generate the movie," Kutcher said. Kutcher, of course, is no stranger to AI.

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