Division of Thoracic and Upper Gastrointestinal Surgery
The Division of Thoracic and Upper Gastrointestinal Surgery is a busy clinical program based at the Montreal General Hospital. The division provides state-of-the-art patient care for a wide range of malignant and non-malignant lung, chest, esophageal and gastric diseases, and is a North American and international leader in many of these fields. As an affiliate of the McGill University School of Medicine, the service functions as an active clinical teaching unit for residents, fellows and medical students, and is widely regarded for its robust clinical and basic science research productivity.
Join us for two talks by Dr. Brendon Stiles, happening at Montreal General Hospital and the RI-MUHC (Glen Site). See below for more details:
Upcoming Event
Join us for "Metalloimmunotherapy: An Emerging Immunology Frontier and Cancer Therapy Modality" - Recruitment Seminar!
We're excited to announce an upcoming recruitment seminar.
Time: Wednesday, March 20, 2024 (3:00 pm – 4:00 pm)
Location: Glen Site, Room EM1.3509
Seminar Abstract:
Metallodrugs have a long track record of disease treatments. Recent studies have shown that metal ions play crucial roles in the regulation of immune pathways. Thus, modulation of interactions between metal ions and the immune system forms the basis of new immunotherapies. We define such therapy as “metalloimmunotherapy”. In this talk, I will introduce how to leverage metal ions for immune modulation and enhanced cancer immunotherapy. I will spotlight a pioneering metalloimmunotherapy integrates stimulators of interferon genes (STING) agonists with nutritional metal ions, which dramatically amplifies STING activation and type-I interferon response. Through pharmaceutical engineering, I developed a highly potent metalloimmunotherapy nanomedicine that shows remarkable success in treating advanced tumors, including those resistant to existing immunotherapies, and in large animal models. Additionally, I will share my findings on the extensive interplay between metal ions and various immune pathways, highlighting new research opportunities and their vast potential in disease management.