McGill.CA / Zhang PainImmunology Lab

Selected Peer Reviewed Publications (Trainees of JZ)

 

 

  1. WB S Zhou, XQ Shi., YN Liu, SD Tran, F Beaudry, J Zhang (2023). Unbiased proteomic analysis detects painful systemic inflammatory profile in the serum of nerve injured mice. Pain 2023 Feb 1;164(2):e77-e90. doi: 10.1097/j.pain.0000000000002695
  2. S Tansley, N Gu, AU Guzmán, EM Pino, C Wong, N Yousefpour, WH Cai, J Heal, N Wu,Castonguay, G Lean, EM Muir, M Prager-Khoutorsky, J Zhang, JW. Fawcett, L Diatchenko, A Riberio-da-Silva, Y De Koninck, JS. Mogil, A Khoutorsky (2022) Microglia-mediated degradation of perineuronal nets promotes pain Science 2022 Jul;377(6601):80-86. doi: 10.1126/science.
  3. MR. Ruff, S Inan, JY Moon, XQ Shi, S Padi, JJ. Meissler, MW. Adler, TK. Eisenstein, J Zhang (2022) Potentiation of Morphine Analgesia and Inhibition of Diabetic Neuropathic Pain by the 2 Multi-Chemokine Receptor Antagonist Peptide RAP-103 Life Sci. 2022 Oct 1;306:120788. doi: 10.1016/j.lfs.2022.120788.
  4. S Tansley, S Uttam, AU Guzmán, M Yaqubi, AS Pacis, M Parisien, O Rabau, L Haglund, J Ouellet, C Santaguida, J Ragoussis, J Zhang, MW Salter, L Diatchenko, L Healy, JS. Mogil, A Khoutorsky (2022) Single-cell RNA sequencing reveals time- and sex-specific responses of spinal cord microglia to peripheral nerve injury and links ApoE to neuropathic pain Nature Communication. 2022 Feb 11;13(1):843. doi: 10.1038/s41467-022-28473-8.
  5. WB S Zhou, WJ Meng, J Zhang (2021) Does low grade systemic inflammation have a role in chronic pain? Front. Mol. Neurosci. 2021 Nov 17; 14:785214
  6. Oladiran, XQ Shi, S Fournier, J Zhang (2021) CX3CR1 but not CCR2 expression is required for the development of autoimmune peripheral neuropathy in mice. Front. Immunol. 2021 Aug 16;12:720733.
  7. Oladiran, XQ Shi, M Yang, S Fournier, J Zhang (2021) Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy Journal of Neuroinflammation 2021 Mar 22;18(1):77.
  8. A Fan, O Oladiran, XQ Shi, J Zhang (2020) Mice on a high-salt diet feel more pain that is mediated by a CCR2 dependent inflammatory mechanism Journal of Neuroinflammation 2020, Jun 9;17(1):179
  9. YH Yang, R Istomine, F Alvarez, T Al-Aubodah, XQ Shi, T Takano, J Zhang, and CA. Piccirillo (2020) Salt-sensing by Serum/Glucocorticoid Regulated Kinase 1 (SGK1) promotes a Th17 phenotype in Foxp3+ regulatory T cells Cell Rep. 2020 Feb 4;30(5):1515-1529
  10. M Millecamps, XQ Shi, M Piltonen, S Echeverry, L Diatchenko, J Zhang, LS. Stone (2019) Cutaneous thresholds, tonic and chronic pain are differentially affected by ageing in mice Neurobiology of Aging 2019 Dec 31. pi: S0197-4580(19)30447-6
  11. Oladiran, M Yang, VA Gimenez Rivera, XQ Shi, JM Huang, S Fournier, J Zhang (2019) Murine cytomegalovirus infection in mice results in an acute inflammatory reaction in peripheral nerves J Neuroimmunol. 2019 Oct 15;335: 577017
  12. M Yang, XQ Shi, C Peyret, S Wu, J Chambon, S Fournier and J Zhang (2018). Effector memory CD8 T cells synergize with co-stimulation competent macrophages to trigger autoimmune peripheral neuropathy in mice Brain Behav Immun. 71:142-157.
  13. GY F Wang, XQ Shi, WJ Wu, M Gueorguieva, M Yang, J Zhang (2018) Sustained mouth opening leads to development of painful temporomandibular disorders involving macrophage/microglia activation in mice Pain 159(7):1277-1288.
  14. SH Lee, XQ Shi, A Fan and J Zhang (2018) Targeting macrophage and microglia activation with colony stimulating factor 1 receptor (CSF1R) inhibitor is an effective strategy to treat injury-triggered neuropathic pain. Molecular Pain 2018 Jan-Dec;14: 1744806918764979.
  15. S Echeverry, XQ Shi, M Yang, H Huang, YC Wu, LE Lorenzo, J Perez-Sanchez, RP. Bonin, Y De Koninck, Ji Zhang (2017). Spinal microglia are required for long term maintenance of neuropathic pain Pain 158(9):1792-1801
  16. Y Yao, S Echeverry, XQ Shi, M Yan, QZ Yang, GYF Wang, J Chambon, YC Wu, KY Fu, Y De Koninck, J Zhang (2016) Dynamics of spinal microglia repopulation following an acute depletion. Scientific Reports 6:22839
  17. M Rone, QL Cui, J Fang, LC Wang, D Khan, J Zhang, R Jones, G Almazan, S Ludwin, T Kennedy, and J Antel (2016) Oligodendrogliopathy in multiple sclerosis: Low glycolytic metabolic rate promotes oligodendrocyte survival. Journal of Neuroscience; 36(17):4698-707
  18. B S Mietto, A Kroner, E I Girolami,XE Santos-Nogueira, J Zhang and S David (2015) Role of IL-10 in Resolution of Inflammation and Functional Recovery after Peripheral Nerve Injury The J of Neuroscience, 35(50):16431–16442
  19. SH Lee, YS Wu, XQ Shi, J Zhang (2015) Characteristics of spinal microglia in aged and obese mice: potential contributions to impaired sensory behavior. Immunity & Ageing. Nov 24; 12:22.
  20. M Yang, C Peyret, XQ Shi, N Siron, JH Jang, S Wu, S Fournier and J Zhang (2015) Evidence from human and animal studies: Pathological roles of CD8+ T cells in autoimmune peripheral neuropathies. Frontiers in Immunology Oct 15; 6:532.
  21. TK Lim, MB Rone, S Lee, JP Antel, J Zhang. (2015) Mitochondrial and bioenergetic dysfunction in trauma-induced painful peripheral neuropathy. Mol Pain. Sep 17; 11(1):58.
  22. RE Sorge, JC Mapplebeck, S Rosen, S Beggs, S Taves S, JK Alexander, LJ Martin, JS Austin, SG Sotocinal, D Chen, M Yang, XQ Shi, H Huang, NJ Pillon, PJ Bilan, Y Tu, A Klip, RR Ji, J Zhang, MW Salter, JS Mogil (2015). Different immune cells mediate mechanical pain hypersensitivity in male and female mice.Nat Neurosci.18(8):1081-3.
  23. TK Lim, XQ Shi, JM Johnson, MB. Rone, JP. Antel, S David, J Zhang. (2015). Peripheral nerve injury induces persistent vascular dysfunction and endoneurial hypoxia, contributing to the genesis of neuropathic pain. Journal of Neuroscience 35(8):3346-59.
  24. J Zhang, S Echeverry, TK Lim, SH Lee, XQ Shi, H Huang. (2015). Can Modulating Inflammatory Response be a Good Strategy to Treat Neuropathic Pain? Current Pharmaceutical Research. 21(7):831-9.
  25. J Zhang. (2015) Peripheral and central immune mechanisms in neuropathic pain, Chapter 7, 109-121, Neuroinflammation: New Insights into Beneficial and Detrimental Functions, Wiley.
  26. M Yang, A Ranoine, XQ Shi, S Fournier, J Zhang (2014) A New Animal Model of Spontaneous Autoimmune Peripheral Polyneuropathy: Implications for Guillain Barré Syndrome Acta Neuropathologica Communications, 2:5, doi:10.1186/2051-5960-2-5
  27. T KY Lim, XQShi, H Huang, H Martin, J Zhang (2014) Blood-nerve barrier dysfunction contributes to the generation of neuropathic pain and allows targeting of injured nerves for pain relief Pain;155(5):954-67.
  28. S Echeverry, YC WU and J Zhang (2013) Selectively reducing cytokine/chemokine expressing macrophages in injured nerves impairs the development of neuropathic pain Experimental Neurology 240:205-18
  29. JV Ragavendran, A Laferrière, WH Xiao, G Bennett, SSV Padi, J Zhang, T Coderre (2012) Topical combinations aimed at treating microvascular dysfunction reduce allodynia in rat models of CRPS-I and neuropathic pain J Pain 14 (1):66-78
  30. SH Lee and J Zhang (2012) Heterogeneity of macrophages in injured trigeminal nerves: Cytokine/chemokine expressing vs. phagocytic macrophages, Brain, Behavior and Immunity 26: 891-903
  31. SSV Padi, Xiang Q Shi, Yuan Q Zhao, Michael R. Ruff, Noel Baichoo, Candace B. Pert, and Ji Zhang (2012) Attenuation of Rodent Neuropathic Pain by an Orally Active Peptide, RAP-103, which Potently Blocks CCR2 and CCR5 Mediated Monocyte Chemotaxis and Inflammation Pain 153(1): 95-106
  32. S Nadeau, M Filali, J Zhang, S Rivest, D Soulet, Y Iwakura, JP de Rivero Vaccari, RW. Keane, and S Lacroix (2011) Functional Recovery after Peripheral Nerve Injury Depends on Proinflammatory Cytokines that Mediate Pain J of Neuroscience 31 (35):12533-12542
  33. S Echeverry, XQ Shi, S Rivest, J Zhang (2011) Peripheral nerve injury alters blood spinal cord barrier functional and molecular integrity through a selective inflammatory pathway J of Neuroscience 31(30):10819-10828
  34. XQ Shi, T Lim, YQ Zhao, J Zhang (2011) Statins alleviate experimental nerve injury induced neuropathic pain Pain 152(5):1033-43
  35. S Echeverry, SH Lee, T Lim, J Zhang (2011) Inflammation mediates nerve injury triggered neuropathic pain In Nerve injury, InTech Open Access Publisher chapter 12, 203-214.
  36. SH Lee, YQ Zhao, A Ribeiro-da-Silva, J Zhang (2010) Distinctive response of CNS glial cells in oro-facial pain associated with injury, infection and inflammation Molecular Pain 6:79
  37. XQ Shi, H Zekki and J Zhang (2010) Role of TLR2 in nerve injury induced-neuropathic pain is essentially mediated through peripheral inflammatory response Glia 59: 231-241
  38. S Echeverry, XQ Shi, A Haw, L Hong, ZW Zhang, J Zhang (2009). Transforming growth factor beta1 impairs neuropathic pain through pleiotropic effect. Molecular Pain 27, 5: 16
  39. J Zhang and Y De Koninck (2009) Abnormal central neuroimmune interactions. In Functional Chronic Pain Syndromes: Similarities and Differences in Clinical Presentation and Pathophysiology, IASP Press,
  40. S Echeverry, XQ Shi, J Zhang (2008). Characterization of cell proliferation in rat spinal cord following peripheral nerve injury. Pain 135 (1-2): 37-47
  41. RJ. Miller, W Rostene, E Apartis, G Banisadr, K Biber, ED. Milligan, FA. White, J Zhang (2008). Chemokine action in the nervous system. J of Neuroscience 28(46):11792-5
  42. J Zhang, XQ Shi, S Echeverry, JS Mogil, Y De Koninck, S Rivest (2007) Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain. J of Neuroscience 27(45): 12396-12406
  43. J Zhang and S Echeverry (2007) Monocyte chemoattractant protein-1 and chronic pain. In Leah R. Grinwald (ed) Chemokine research trends, Novapublishers. Chapter 7, p107-120.
  44. J. Zhang, Y. De Koninck (2006). Spatial and temporal relationship between MCP-1 expression and spinal microglial activation following peripheral nerve injury. J.Neurochem. 97, 772-783
  45. J Zhang (2006). Involvement of monocyte chemoattractant protein-1 in peripheral nerve injury induced neuropathic pain. Reviews in Analgesia 9: 13-20.
  46. J Zhang and S Rivest (2004) Arachidonate metabolites in neurophysiological system: The fever pathway. In The Eicosanoids JohnWiley& Sons Limited. Chapter 42, 463-472.
  47. F Mennicken, J Zhang, C Hoffert, S Ahmad, A Beaudet, D O’Donnell (2003). Phylogenetic changes in the expression of delta opioid receptors in spinal cord and dorsal root ganglia. J. Comp. Neurol. 465(3): 349-60.
  48. J Zhang, C Hoffert, HK Vu, T Groblewski, S Ahmad, D O’Donnell (2003). Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models. Eur. J. Neurosci, 17(12): 2750-4.
  49. J Zhang and S Rivest (2003). Is survival possible without arachidonate metabolites in the brain during systemic infection? News in Physiological Sciences, 18:137-142.
  50. PMC Lembo, E Grazzini, T Groblewski, D O'Donnell, M-O Roy, J Zhang, C Hoffert, J Cao, R Schmidt, M Pelletier, M Labarre, M Gosselin, Y Fortin, D Banville, SH Shen, P Ström, K Payza, A Dray, P Walker & S Ahmad (2002). Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. Nature Neuroscience, Vol 5, No 3: 201-209
  51. V Blais, J Zhang, S Rivest (2002). In altering the release of glucocorticoids, ketorolac exacerbates the effects of systemic immune stimuli on expression of proinflammatory genes in the brain. Endocrinology, 143(12): 4820-7.
  52. J Zhang and S Rivest (2001). Anti-inflammatory effects of prostaglandin E2 in the central nervous system in response to brain injury and circulating lipopolysaccharide. J.Neurochem. 2001 Feb; 76(3): 855-64.
  53. J Zhang and S Rivest. (2000). A functional analysis of EP4 receptor-expressing neurons in mediating the action of prostaglandin E2 within specific nuclei of the brain in response to circulating interleukin-1beta. J. Neurochem. 74 (5): 2134-45.
  54. S Rivest, S Lacroix, L Valliere, S Nadeau, J Zhang and N Laflamme (2000). How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli. Proc. Soc. Exp. Biol. Med. 223 (1): 22-38.
  55. J Zhang and S Rivest (1999). Distribution, regulation and colocalization of the genes encoding the EP2- and EP4-PGE2 receptors in the rat brain and neuronal responses to systemic inflammation. Eur. J. Neurosci. 11 (8): 2651-68

 

 

 

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