Application: Targeted screening and quantification of chemical compounds simultaneously in metabolomics and clinical analysis. Specialized in protein metabolism. Recent applications include measurement of deuterated phenylalanine in plasma and tissue for protein synthesis; measurement of glutathione and related metabolite concentration in plasma and tissues; measurement of choline, betaine, methionine and dimethyl glycine for analysis of 1-C metabolism.
Instruments parameters:
- Ionization modes: ± ES
- Operating modes: MS scan; MS/MS product ion scan; MRM; MS/MS neutral loss/gain scan and precursor ion scan; SIM.
- m/z range: 5-3000
- Mass Accuracy: 0.1-0.6 Da
- Sample inlets: Agilent 1290 UHPLC