Équipe

Orniacki, C., Verrico, A., Souquet, B., Pelletier, S., Jourdren, L., Coulpier, F., Benetti, S., Doye V. (2022). Y-complex nucleoporins independently contribute to nuclear pore assembly and gene regulation in neuronal progenitors. J. Cell Sci. 136, jcs261151.

Gonzalez-estevez, A.*, Verrico, A.*, Orniacki, C., Reina-San-Martin B., Doye V. (2021). Integrity of the short arm of nuclear pore Y-complex is required for mouse embryonic stem cell growth and differentiation. J. Cell Sci. 134. jcs258340.

Langouët, M., Gorka, D., Orniacki, C., Dupont-Thibert, C.M., Chung, M.S., Glatt-Deeley, H.R., Germain, N., Crandall, L.J., Cotney, J.L., Stoddard, C.E., Lalande M., Chamberlain S.J. (2020) Specific ZNF274 binding interference at SNORD116 activates the maternal transcripts in Prader-Willi syndrome neurons. Human Mol. Genetics 29. 3285-3295.

Yi, W., MacDougall, E. J., Tang, M. Y., Krahn, A. I., Gan-Or, Z., Trempe, J. Fon, E. A. (2019) The landscape of Parkin variants reveals pathogenic mechanisms and therapeutic targets in Parkinson’s disease. Hum. Mol. Genet. 28, 2811–2825

Fava, V. M., Xu, Y. Z., Lettre, G., Van Thuc, N., Orlova, M., Thai, V. H., Tao, S., Croteau, N., Eldeeb, M. A., MacDougall, E. J., Cambri, G., Lahiri, R., Adams, L., Fon, E. A., Trempe, J., Cobat, A., Alcaïs, A., Abel, L., Schurr, E. (2019) Pleiotropic effects for Parkin and LRRK2 in leprosy type-1 reactions and Parkinson’s disease. Proc. Natl. Acad. Sci. U.S.A. 116, 15616–15624

Eldeeb, M. A., MacDougall, E. J., Ragheb, M. A., Fon, E. A. (2019) Beyond ER: Regulating TOM-Complex-Mediated Import by Ubx2. Trends Cell Biol. 29, 687–689

Khoo S.Y.-S., Lecocq M.,Deyab, G., Chaudhri, N. (2019) Context and topography determine the role of basolateral amygdala metabotropic glutamate receptor 5 in appetitive Pavlovian responding. Neuropsychopharmacology 44(9):1524-1533

Arshad H, Patel Z, Mehrabian M, Bourkas MEC, Al-Azzawi ZAM, Schmitt-Ulms G, Watts JC. (2021) The aminoglycoside G418 hinders de novo prion infection in cultured cells. J Biol Chem. 297(3):101073

So RWL, Chung SW, Lau HHC, Watts JJ, Gaudette E, Al-Azzawi ZAM, Bishay J, Lin LT, Joung J, Wang X, Schmitt-Ulms G. (2019) Application of CRISPR genetic screens to investigate neurological diseases. Mol Neurodegener. 14(1):41.

Bourkas MEC, Arshad H, Al-Azzawi ZAM, Halgas O, Shikiya RA, Mehrabian M, Schmitt-Ulms G, Bartz JC, Watts JC. (2019) Engineering a murine cell line for the stable propagation of hamster prions. J Biol Chem. 294(13):4911-4923.

Worrall D, Ayoubi R, Fotouhi M, Southern K, McPherson PS, Laflamme C, NeuroSGC/YCharOS/EDDU collaborative group, ABIF Consortium. (2023) The identification of high-performing antibodies for TDP-43 for use in Western Blot, immunoprecipitation and immunofluorescence.  F1000Research 12, 277

Ayoubi R, Ryan J, Biddle MS, Alshafie W, Fotouhi M, Bolivar SG, Ruiz Moleon V, Eckmann P, Worrall D, McDowell I, Southern K, Reintsch W, Durcan TM, Brown C, Bandrowski A, Virk H, Edwards AM, McPherson P, Laflamme C (2023) Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications.  eLife 12, RP91645

Ayoubi R, Worrall D, et al. (2023) Antibody Characterization Report for Angiogenin.  Zenodo 

Fotouhi M, Ryan J, Reintsch W, Worrall D, et al. (2023) Antibody Characterization Report for Alsin.  Zenodo 

Fotouhi M, Ryan J, Worrall D, et al. (2023) Antibody Characterization Report for RNA-binding protein TIA1. Zenodo 

Worrall D, et al. (2022) Antibody Characterization Report for Rho Gdp-dissociation Inhibitor 1 (rho GDI 1).  Zenodo 

Roberts R., Bayne AN., Goiran T., Lévesque D., Boisvert FM., Trempe JF., Fon EA., (2021). Proteomic Profiling of Mitochondrial-Derived Vesicles in Brain Reveals Enrichment of Respiratory Complex Sub-assemblies and Small TIM Chaperones. J Proteome Res ; 20(1):506-517.

Checler F, Goiran T, Alves da Costa C. (2018). Nuclear TP53: An unraveled function as transcriptional repressor of PINK1. Autophagy ; 14(6):1099-1101.

McLelland GL, Goiran T, Yi W, Dorval G, Chen CX, Lauinger ND, Krahn AI, Valimehr S, Rakovic A, Rouiller I, Durcan TM, Trempe JF, Fon EA. (2018). Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy. Elife ; pii: e32866

Goiran T, Duplan E, Rouland L, El Manaa W, Lauritzen I, Dunys J, You H, Checler F, Alves da Costa C. (2018). Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation. Cell Death and Differentiation ; 25(5):873-884

Goiran T, Duplan E, Chami M, Bourgeois A, El Manaa W, Rouland L, Dunys J, Lauritzen I, You H, Stambolic V, Biféri MG, Barkats M, Pimplikar SW, Sergeant N, Colin M, Morais VA, Pardossi-Piquard R, Checler F, Alves da Costa C. (2018). β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models. Biological Psychiatry ; 1;83(5):416-427

Checler F, Goiran T, Alves da Costa C. (2017). Presenilins at the crossroad of a functional interplay between PARK2/PARKIN and PINK1 to control mitophagy: Implication for neurodegenerative diseases. Autophagy ; 13(11):2004-2005

CLoubière C, Goiran T, Laurent K, Djabari Z, Tanti JF, Bost F. (2015). Metformin-induced energy deficiency leads to the inhibition of lipogenesis in prostate cancer cells. Oncotarget ; 20;6(17):15652-61

Viotti J, Duplan E, Caillava C, Condat J, Goiran T, Giordano C, Marie Y, Idbaih A, Delattre JY, Honnorat J, Checler F, Alves da Costa C. (2014). Glioma tumor grade correlates with parkin depletion in mutant p53- linked tumors and results from loss of function of p53 transcriptional activity. Oncogene ; 3;33(14):1764-75

Duplan E, Sevalle J, Viotti J, Goiran T, Bauer C, Renbaum P, Levy-Lahad E, Gautier CA, Corti O, Leroudier N, Checler F, da Costa CA. (2013). Parkin differently regulates presenilin-1 and presenilin-2 functions by direct control of their promoter transcription. Journal of Molecular Cell Biology ; Apr;5(2):132-42

Del Cid-Pellitero E, Tavassoly O, Larroquette F, Cai E, Thomas RA, Soubannier V, Luo W, Durcan TM, Fon EA. (2021) Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation. Neurotherapeutics. 

Vogel JW, La Joie R, Grothe MJ, Diaz-Papkovich A, Doyle A, Vachon-Presseau E, Lepage C, de Wael RV, Thomas RA, Iturria-Medina Y, Bernhardt B. (2020) A molecular gradient along the longitudinal axis of the human hippocampus informs large-scale behavioral systems. Nature communications 11(1):1-7

Thomas RA, Gibon J, De Leon, A, Chen, CXQ, Chierzi, S, Baulac, S, Murai, KK, Barker PA. (2018) The Nogo Receptor Ligand LGI1 Regulates Synapse Number and Synaptic Activity in Hippocampal and Cortical Neurons. eNeuro 0185-18

Thomas RA, Metzen MG and Chacron MJ. (2018) Weakly electric fish distinguish between envelope stimuli arising from different behavioral contexts. Journal of experimental biology 221: jeb178244

Gibon J, Unsain N, Gamache K, Thomas RA, De Leon A, Johnstone A, Nader K, Sequela P, Barker PA. (2016) The X-linked inhibitor of apoptosis regulates long-term depression and learning rate. FASEB J. 30(9):3083

Thomas RA, Ambalavana A, Rouleau GA, Barker PA. (2016) Identification of genetic variants of LGI1 and RTN4R (NgR1) linked to schizophrenia that are defective in NgR1–LGI1 signaling. Molecular Genetics and Genomic Medicine. 4(4): 447–456

Kommaddi R, Thomas R, Ceni C, Daigneault K, Barker PA. (2011) Trk-dependent ADAM17 activation facilitates neurotrophin survival signalling. FASEB J. 10-173740

Ceni C, Kommaddi R, Thomas R, Vereker E, McPherson PM, Ritter B, Liu X, Barker PA. (2010) The p75NTR intracellular domain is generated by neurotrophin-induced receptor cleavage to potentiate Trk signalling. Journal of Cell Science 123(13):2299-307

Thomas R, Favell K, Morante-Redolat JM, Pool, M, Kent C, Wright M, Daignault K, Ferraro G, Montcalm S, Durocher Y, Fournier A, Perez-Tur J, Barker PA. (2010) LGI1 is a Novel Nogo Receptor 1 ligand that antagonizes myelin-based growth inhibition. Journal of Neuroscience 30(19):6607-12

Choquet K, Pinard M, Yang S, Moir RD, Poitras C, Dicaire M-J, Sgarioto N, Larivière R, Kleinman CL, Willis IM, Gauthier M-S, Coulombe B, Brais B. (2019) The leukodystrophy mutation Polr3b R103H causes homozygote mouse embryonic lethality and impairs RNA Polymerase III biogenesis. Mol. Brain

Larivière R, Sgarioto N, Toscano Márquez B, Gaudet R, Choquet K, McKinney RA, Watt AJ, Brais B. (2019) Sacs R272C missense homozygous mice develop an ataxia phenotype. Mol. Brain

Walker CL, Uchida A, Li Y, Trivedi N, Fenn JD, Monsma PC, Larivière RC, Julien JP, Jung P, Brown A. (2019) Local Acceleration of Neurofilament Transport at Nodes of Ranvier. J Neurosci.

Gentil BJ, Lai GT, Menade M, Larivière R, Minotti S, Gehring K, Chapple JP, Brais B, Durham HD. (2018) Sacsin, mutated in the ataxia ARSACS, regulates intermediate filament assembly and dynamics. FASEB J.

Ady V, Toscano-Márquez B, Nath M, Chang PK, Hui J, Cook A, Charron F, Larivière R, Brais B, McKinney RA, Watt AJ. (2018) Altered synaptic and firing properties of cerebellar Purkinje cells in a mouse model of ARSACS. J Physiol.

Duncan EJ, Larivière R , Bradshaw TY, Longo F, Sgarioto N, Hayes MJ, Romano LEL, Nethisinghe S, Giunti P, Bruntraeger MB, Durham HD, Brais B, Maltecca F, Gentil BJ, Chapple JP. (2017) Altered organization of the intermediate filament cytoskele-ton and relocalization of proteostasis modulators in cells lacking the ataxia protein sacsin. Hum Mol Genet.

Choquet K, Yang S, Moir RD, Forget D, Larivière R , Bouchard A, Poitras C, Sgarioto N, Dicaire MJ, Noohi F, Kennedy TE, Roch-ford J, Bernard G, Teichmann M, Coulombe B, Willis IM, Klein-man CL, Brais B. (2017) Absence of neurological abnormalities in mice homozygous for the Polr3a G672E hypomyelinating leukodystrophy mutation. Mol Brain.

Larroquette F, Seto L, Gaub PL, Kamal B, Wallis D, Larivière R, Vallée J, Robitaille R, Tsuda H. (2015) Vapb/Amyotrophic lateral sclerosis 8 knock-in mice display slowly progressive motor behavior defects accompanying ER stress and autophagic response. Hum Mol Genet.

Larivière R, Gaudet R, Gentil BJ, Girard M, Conte TC, Minotti S, Leclerc-Desaulniers K, Gehring K, McKinney RA, Shoubridge EA, McPherson PS, Durham HD, Brais B. (2015) Sacs knockout mice present pathophysiological defects underlying autosomal recessive spastic ataxia of Charlevoix-Saguenay. Hum Mol Genet.

Thiffault I, Dicaire MJ, Tetreault M, Huang KN, Demers-La-marche J, Bernard G, Duquette A, Larivière R, Gehring K, Montpetit A, McPherson PS, Richter A, Montermini L, Mercier J, Mitchell GA, Dupré N, Prévost C, Bouchard JP, Mathieu J, Brais B. (2013) Diversity of ARSACS mutations in French-Canadians. Can J Neurol Sci.

Girard M1, Larivière R1, Parfitt DA, Deane EC, Gaudet R, Noss-ova N, Blondeau F, Prenosil G, Vermeulen EGM, Duchen MR, Richter A, Shoubridge EA, Gehring K, McKinney RA, Brais B, Chapple JP, and McPherson PS. (2012 10) Mitochondrial dysfunction and Purkinje cell loss in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) PNAS (1: co-authors)

Ezzi SA, Larivière R, Urushitani M, Julien JP. (2010) Neuronal over-ex-pression of chromogranin A accelerates disease onset in a mouse model of ALS. J. Neurochem.

Dequen F, Filali M, Larivière RC, Perrot R, Hisanaga S, Julien JP. (2010) Reversal of neuropathy phenotypes in conditional mouse model of Charcot-Marie-Tooth disease type 2E. Hum Mol Genet.

Gros-Louis F, Soucy G, Larivière R, Julien JP. (2010) Intracerebroven-tricular infusion of monoclonal antibody or its derived Fab fragment against misfolded forms of SOD1 mutant delays mortality in a mouse model of ALS. J Neurochem.

Eriksson KS, Zhang S, Lin L, Larivière RC, Julien JP, Mignot E. (2008) The type III neurofilament peripherin is expressed in the tubero-mammillary neurons of the mouse. BMC Neurosci.

Millecamps S, Robertson J, Lariviere R, Mallet J, Julien JP. (2006) Defective axonal transport of neurofilament proteins in neurons overexpressing peripherin. J Neurochem.

Gros-Louis F, Larivière R, Gowing G, Laurent S, Camu W, Bouchard JP, Meininger V, Rouleau GA, Julien JP. (2004) A frameshift deletion in peripherin gene associated with amyotrophic lateral sclerosis. J Biol Chem.

Nguyen MD, Shu T, Sanada K, Larivière RC, Tseng HC, Park SK, Julien JP, Tsai LH. (2004) A NUDEL¬dependent mechanism of neurofil-ament assembly regulates the integrity of CNS neurons. Nat Cell Biol.

Lariviere RC, Julien JP. (2004) Functions of intermediate filaments in neuronal development and disease. J Neurobiol. Review.

Larivière RC, Beaulieu JM, Nguyen MD, Julien JP. (2003) Peripherin is not a contributing factor to motor neuron disease in a mouse model of amyotrophic lateral sclerosis caused by mutant superoxide dismutase. Neurobiol Dis.

Larivière RC, Nguyen MD, Ribeiro-da-Silva A, Julien JP. (2002) Reduced number of unmyelinated sensory axons in peripher-in null mice. J Neurochem.

Nguyen MD, Larivière RC, Julien JP. (2001) Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofil-ament inclusions. Neuron.

Nguyen MD, Larivière RC, Julien JP. (2000) Reduction of axonal caliber does not alleviate motor neuron disease caused by mutant superoxide dismutase 1. Proc Natl Acad Sci U S A.

Del Cid-Pellitero E, Tavassoly O, Larroquette F, Cai E, Thomas RA,Soubannier V, Luo W, Durcan TM, Fon EA. (2021) Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation. Neurotherapeutics. 

Jefri M, Bell S, Peng H, Hettige N, Maussion G, Soubannier V , Wu H, Silveira H, Theroux JF, Moquin L, Zhang X, Aouabed Z, Krishnan J, O'Leary LA, Antonyan L, Zhang Y, McCarty V, Mechawar N, Gratton A, Schuppert A, Durcan TM, Fon EA, Ernst C. (2020) Stimulation of L-type calcium channels increases tyrosine hydroxylase and dopamine in ventral midbrain cells induced from somatic cells. Stem Cells Transl Med.

Methot L, Soubannier V, Hermann R, Campos E, Li S, Stifani S. (2018) Nuclear factor-kappaB regulates multiple steps of gliogenesis in the developing murine cerebral cortex. Glia

Thomas RA, Gibon J, Chen CXQ, Chierzi S, Soubannier V, Baulac S, Séguéla P, Murai K, Barker PA. (2018) The Nogo Receptor Ligand LGI1 Regulates Synapse Number and Synaptic activity in Hippocampal and Cortical Neurons. eNeuro

Bell S, Maussion G, Jefri M, Peng H, Theroux JF, Silveira H, Soubannier V, Wu H, Hu P, Galat E, Torres-Platas SG, Boudreau-Pinsonneault C, O'Leary LA, Galat V, Turecki G, Durcan TM, Fon EA, Mechawar N, Ernst C. (2018) Disruption of GRIN2B Impairs Differentiation in Human Neurons. Stem Cell Reports.

Soubannier V, Stifani S. (2017) NF-κB Signalling in Glioblastoma. Biomedicines.

Gaub P, de Léon A, Gibon J, Soubannier V, Dorval G, Séguéla P, Barker PA. (2016) HBpF-proBDNF: A New Tool for the Analysis of Pro-Brain Derived Neurotrophic Factor Receptor Signaling and Cell Biology. PloS One.

Patten DA, Wong J, Khacho M, Soubannier V, Mailloux RJ, Pilon-Larose K, MacLaurin JG, Park DS, McBride HM, Trinkle-Mulcahy L, Harper ME, Germain M, Slack RS. (2014) OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand. EMBO J.

McLelland GL, Soubannier V, Chen CX, McBride HM, Fon EA. (2014) Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control. EMBO J.

Soubannier V, Rippstein P, Kaufman BA, Shoubridge EA, McBride HM. (2012) Reconstitution of mitochondria derived vesicle formation demonstrates selective enrichment of oxidized cargo. PloS One.

Soubannier V,McLelland GL, Zunino R, Braschi E, Rippstein P, Fon EA, McBride HM. (2012) A vesicular transport pathway shuttles cargo from mitochondria to lysosomes. Curr. Biol.

McBride H, Soubannier V (2010) Mitochondrial function: OMA1 and OPA1, the grandmasters of mitochondrial health. Curr. Biol.

Rabl R, Soubannier V, Scholz R, Vogel F, Mendl N, Vasiljev-Neumeyer A, Körner C, Jagasia R, Keil T, Baumeister W, Cyrklaff M, Neupert W, Reichert AS. (2009) Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g. J. Cell. Biol.

Soubannier V, McBride HM. (2009) Positioning mitochondrial plasticity within cellular signaling cascades. Biochim. Biophys. Acta.

Giraud MF, Paumard P, Soubannier V, Vaillier J, Arselin G, Salin B, Schaeffer J, Brèthes D, di Rago JP, Velours J. (2002) Is there a relationship between the supramolecular organization of the mitochondrial ATP synthase and the formation of cristae? Biochim. Biophys. Acta.

Paumard P, Vaillier J, Coulary B, Schaeffer J, Soubannier V, Mueller DM, Brèthes D, di Rago JP, Velours J. (2002) The ATP synthase is involved in generating mitochondrial cristae morphology. EMBO J.

Soubannier V, Vaillier J, Paumard P, Coulary B, Schaeffer J, Velours J. (2002) In the absence of the first membrane-spanning segment of subunit 4(b), the yeast ATP synthase is functional but does not dimerize or oligomerize. J. Biol. Chem.

Velours J, Vaillier J, Paumard P, Soubannier V, Lai-Zhang J, Mueller DM. (2001) Bovine coupling factor 6, with just 14.5% shared identity, replaces subunit h in the yeast ATP synthase. J. Biol. Chem.

Velours J, Paumard P, Soubannier V, Spannagel C, Vaillier J, Arselin G, Graves PV. (2000) Organisation of the yeast ATP synthase F(0):a study based on cysteine mutants, thiol modification and cross-linking reagents. Biochim. Biophys. Acta.

Soubannier V, Rusconi F, Vaillier J, Arselin G, Chaignepain S, Graves PV, Schmitter JM, Zhang JL, Mueller D, Velours J. (1999) The second stalk of the yeast ATP synthase complex: identification of subunits showing cross-links with known positions of subunit 4 (subunit b). Biochemistry

Tavassoly O, Del Cid-Pellitero E, Larroquette F, Cai E, Thomas RA, Soubannier V, Luo W, Durcan TM, Fon EA. (2021) Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation. Neurotherapeutics. 

Mohamed NV, Larroquette F., Beitel LK, Fon EA, Durcan TM. (2019) One step into the future: new iPSC tools to advance research in Parkinson’s disease and neurological disorders. Journal of Parkinson’s disease doi: 10.3233/JPD-181515

Larroquette F, Seto L, Gaub PL, Kamal B, Wallis D, Larivière R, Vallée J, Robitaille R, Tsuda H. (2015) Vapb/Amyotrophic lateral sclerosis 8 knock-in mice display slowly progressive motor behavior defects accompanying ER stress and autophagic response. Human Molecular Genetics ; 24(22):6515-29.