The Neuroinformatics for Personalized Medicine toolBox (NeuroPM-box) is a free cross-platform user-friendly multitool software for advanced integration of molecular, histopathological, multimodal neuroimaging, and therapeutic data. Developed by Prof. Yasser Ituria Medina's lab (NeuroPM Lab), its aim is to synergize the different methods and data modalities, to facilitate the discovery of novel and more efficient methods for multiscale and multifactorial data analysis, and the subsequent patients stratification. It is a standalone software applications for Windows, Linux and Mac, and includes a user-friendly interface (GUI) and visualization which does not require programming expertise. It also provides an easy-to-follow tutorial to help you get started.
The toolbox currently comprises five methodological implementations:
- contrastive Trajectories Inference (cTI): identifying biomarker trajectories, patients disease progression scores and subtypes;
- Multi-omics contrastive Trajectories Inference (multi-cTI): identifying biomarker trajectories, patients disease progression scores and subtypes based on multiple layers of omics data;
- Epidemic Spreading Model (ESM): characterizing molecular or macroscopic region-region "agents" (e.g. tau, amyloid, atrophy) spreading through brain networks at both individual and group level;
- Multifactorial Causal Model (MCM): characterizing complex synergistic interactions between multiple imaging-derived biological factors, and their concurrent intra-brain propagation at both individual and group level;
- personalized Therapeutic Fingerprints (pTIF): subtyping of patients for personalized treatment based on multi-modal imaging-derived individual brain deformations required to modulate disease trajectory.
NeuroPM-box is shared freely with academics and not-for-profit researchers, for non-commercial use only. For commercial use, the Neuro-PM lab undertakes the analysis. Funding obtained from for-profit users will be in turn used for software extension/maintenance and to support the lab’s research. If you are interested in using the Software commercially, please contact yasser.iturriamedina [at] mcgill.ca (Prof. Yasser Iturria Medina).
