Killam Seminar Series: Molecular Mechanisms Controlling Dopamine Neuron Biology in Health and Disease
Grâce à la générosité des fiducies Killam, Le Neuro convoque lors d’une série de séminaires des conférenciers d’exception dont les travaux passionnent ses chercheurs et ceux de l’Université McGill.
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Helen Bateup, PhD
Professeure associée, Département de biologie moléculaire et cellulaire, UC Berkely, États-Unis
Hôte: j-francois.poulin [at] mcgill.ca (Jean-François Poulin)
Abstract: Dopamine neurons represent a small fraction of neurons in the brain, yet they exert widespread influence over a variety of brain systems that control motor function, reward, motivation, and learning. Recent work from our lab and others has uncovered considerable diversity within the dopaminergic system, which likely underlies its pleotropic functions. Importantly, dysfunction of different classes of dopamine neurons contribute to neuropsychiatric and neurodegenerative disorders. In this talk, I will present our work investigating the molecular pathways that regulate dopaminergic function. In particular, I will discuss our findings showing that mTOR, a central regulator of cell growth and metabolism, is a key modulator of dopamine neuron structure and function. I will present data from mouse models showing that balanced mTOR activity is critical for proper dopaminergic output, as suppression or overactivation of mTOR has detrimental effects on multiple aspects of dopamine neuron biology. In addition, I will discuss our ongoing collaborative work to investigate the pathways that contribute to dopamine neuron degeneration in the context of Parkinson’s disease, using functional genomics approaches in human midbrain organoids.
