Killam Seminar Series: Single-Cell Approaches to Studying Connectivity and Neuronal States During Fear Learning

Grâce à la générosité des fiducies Killam, Le Neuro convoque lors d’une série de séminaires des conférenciers d’exception dont les travaux passionnent ses chercheurs et ceux de l’Université McGill. 

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Amit Zeisel

Professeur adjoint, Faculté de biotechnologie et de génie alimentaire, Institut de nanotechnologie Russell Berrie, Israël.

Hôte: j-francois.poulin [at] mcgill.ca (Jean-François Poulin)

Abstract: In this seminar, Amit Zeisel will cover two topics investigated in his lab. The first part involves the generation of a comprehensive cellular taxonomy of the mouse amygdala. By employing single-cell RNA sequencing, his team has identified distinct neuronal subtypes and their specific transcriptional profiles. This work enables the mapping of cell-type-specific transcriptional responses during the consolidation of the fear conditioning process, providing insights into the molecular underpinnings of fear memory formation. In the second part, Amit Zeisel will introduce methods for constructing brain-wide monosynaptic connectivity maps. Utilizing a barcoded rabies virus, his lab has developed a novel approach to trace and map the synaptic connections of individual neurons across the brain.