Josephine Nalbantoglu, PhD
Josephine Nalbantoglu s’intéresse à la génétique moléculaire de la maladie d’Alzheimer, à la régulation de l’expression génique dans le système nerveux et à la thérapie génique pour les tumeurs au cerveau. Pour l’étude du rôle du métabolisme et du dépôt de l’amyloïde dans la maladie d’Alzheimer, son laboratoire a généré des souris transgéniques qui expriment un fragment du précurseur du peptide ß-amyloïde humain (APP). Les souris manifestent des signes de lésion tissulaire et de déficits comportementaux qui sont analogues aux changements survenant dans la maladie d’Alzheimer. Elle a aussi étudié le contrôle de l’expression génique de l’APP en caractérisant d’importantes séquences régulatrices de gènes et les protéines qui s’y lient. Elle collabore avec le DrGeorge Karpati à la thérapie génique à médiation par adénovirus de gliomes et de médulloblastomes expérimentaux au moyen de gènes suppresseurs de tumeur et de gènes suicides.
Dudley RW, Lu Y, Gilbert R, Matecki S, Nalbantoglu J, Petrof BJ, Karpati G.
Abstract Sustained improvement of muscle function one year after full-length dystrophin gene transfer into mdx mice by a gutted helper-dependent adenoviral vector. Hum Gene Ther. 2004 Feb;15(2):145-56. PMID: 14975187 [PubMed - in process]
Batulan Z, Shinder GA, Minotti S, He BP, Doroudchi MM, Nalbantoglu J, Strong MJ, Durham HD.
Abstract High threshold for induction of the stress response in motor neurons is associated with failure to activate HSF1. J Neurosci. 2003 Jul 2;23(13):5789-98. PMID: 12843283 [PubMed - indexed for MEDLINE]
Gilbert R, Dudley RW, Liu AB, Petrof BJ, Nalbantoglu J, Karpati G.
Abstract Prolonged dystrophin expression and functional correction of mdx mouse muscle following gene transfer with a helper-dependent (gutted) adenovirus-encoding murine dystrophin. Hum Mol Genet. 2003 Jun 1;12(11):1287-99. PMID: 12761044 [PubMed - indexed for MEDLINE]
Wosik K, Antel J, Kuhlmann T, Bruck W, Massie B, Nalbantoglu J.
Abstract Oligodendrocyte injury in multiple sclerosis: a role for p53. J Neurochem. 2003 May;85(3):635-44. PMID: 12694389 [PubMed - indexed for MEDLINE]
Nalbantoglu J, Larochelle N, Wolf E, Karpati G, Lochmuller H, Holland PC.
Free Full Text Muscle-specific overexpression of the adenovirus primary receptor CAR overcomes low efficiency of gene transfer to mature skeletal muscle. J Virol. 2001 May;75(9):4276-82. PMID: 11287577 [PubMed - indexed for MEDLINE]
Wosik K, Becher B, Ezman A, Nalbantoglu J, Antel JP.
Abstract Caspase 8 expression and signaling in Fas injury-resistant human fetal astrocytes. Glia. 2001 Mar 1;33(3):217-24. PMID: 11241739 [PubMed - indexed for MEDLINE]
Ladiwala U, Li H, Antel JP, Nalbantoglu J. Abstract p53 induction by tumor necrosis factor-alpha and involvement of p53 in cell death of human oligodendrocytes. J Neurochem. 1999 Aug;73(2):605-11. PMID: 10428056 [PubMed - indexed for MEDLINE]
Ghribi O, Lapierre L, Girard M, Ohayon M, Nalbantoglu J, Massicotte G.
Abstract Hypoxia-induced loss of synaptic transmission is exacerbated in hippocampal slices of transgenic mice expressing C-terminal fragments of Alzheimer amyloid precursor protein. Hippocampus. 1999;9(3):201-5. PMID: 10401636 [PubMed - indexed for MEDLINE]
Galipeau J, Li H, Paquin A, Sicilia F, Karpati G, Nalbantoglu J.
Free Full Text Vesicular stomatitis virus G pseudotyped retrovector mediates effective in vivo suicide gene delivery in experimental brain cancer. Cancer Res. 1999 May 15;59(10):2384-94. PMID: 10344748 [PubMed - indexed for MEDLINE]
Nalbantoglu J, Pari G, Karpati G, Holland PC.
Abstract Expression of the primary coxsackie and adenovirus receptor is downregulated during skeletal muscle maturation and limits the efficacy of adenovirus-mediated gene delivery to muscle cells. Hum Gene Ther. 1999 Apr 10;10(6):1009-19. PMID: 10223734 [PubMed - indexed for MEDLINE]
Li H, Alonso-Vanegas M, Colicos MA, Jung SS, Lochmuller H, Sadikot AF, Snipes GJ, Seth P, Karpati G, Nalbantoglu J.
Free Full Text Intracerebral adenovirus-mediated p53 tumor suppressor gene therapy for experimental human glioma. Clin Cancer Res. 1999 Mar;5(3):637-42. PMID: 10100717 [PubMed - indexed for MEDLINE]
Nalbantoglu J, Tirado-Santiago G, Lahsaini A, Poirier J, Goncalves O, Verge G, Momoli F, Welner SA, Massicotte G, Julien JP, Shapiro ML.
Abstract Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein. Nature. 1997 May 29;387(6632):500-5. PMID: 9168112 [PubMed - indexed for MEDLINE]
Shekarabi M, Bourbonniere M, Dagenais A, Nalbantoglu J.
Abstract Transcriptional regulation of amyloid precursor protein during dibutyryl cyclic AMP-induced differentiation of NG108-15 cells. J Neurochem. 1997 Mar;68(3):970-8. PMID: 9048742 [PubMed - indexed for MEDLINE]
