Standard Operating Procedures (SOPs)

Draft SOPs for reviewAnalgesia | Anesthesia | Surgery | Euthanasia | Experimental Guidelines | Animal Care Veterinary Care | Monitoring Log templateOccupational Health and Safety | SAILFarm SOPs | Body Conditioning Score | Controlled drug SOPControlled Substances Requirements | PHAC Biohazard info | ALPHA Certificate 

Standard Operating Procedures (SOPs) provide a detailed description of commonly used procedures. SOPs offer investigators an alternative to writing detailed procedures in their protocol. Any deviation from the approved procedures must be clearly described and justified in the Animal Use Protocol application in Darwin. Approval of the protocol indicates approval of the deviation from the SOP for that project only.

The following Standard Operating Procedures (SOPs) were created and/or revised by the Veterinary Care Subcommittee and/or the Occupational Health and Safety Subcommittee, and approved by the University Animal Care Committee.

If you have questions or have a recommendation to make, please send an animalcare [at] (email) or talk to the Veterinarian in your area.

DRAFT REVISED AND NEW SOPs - None at the moment












Experimental Guidelines:   



  This Monitoring Log is to be  This Monitoring Log is to be prepared by the Facility Animal Care Committee as per the approved Animal Use Protocol:  File Monitoring log TEMPLATE - Oct 2017  

Tumor Volume

Metastatic Model Monitoring log  <- is a log

Mammary Gland Identification Mouse

Tumor Monitoring Log  <- is a log 


Animal Care:  


Veterinary Care: 



Occupational Health and Safety: 




Body Condition Score:

Body Condition Score Outline Mice (BCS)
Body Condition Score Outline For Rats (BCS)

Of interest: Article Body Condition Score for Rats

Requirements on Record Keeping, Storage and Disposal of Controlled Substances

The storage conditions and physical security for the controlled substance must meet the requirements of the "Directive on Physical Security Requirements for Controlled Substances", available on the Health Canada website.

For scientific exemptions, the required security level is Security Level - 1 and the maximum licensee holdings is $5000. Please note that each researcher must have his or her own storage.

The conditions of record keeping and disposal is outlined in the exemption letter as follows:

The researcher is required to maintain records with respect to his/her possession and use of the controlled substance in accordance with the applicable regulations. The researcher shall furnish such information respecting such controlled substances as the Minister may requires and shall permit access to the records required to be kept by these Regulations. Specifically, the researcher must keep and retain for a period of two years from the making of such record, the following information:

• the kind, date and quantity of any controlled substance purchased or received;
• the name and address of the person from whom the controlled substance was received; and particulars of the use to which the controlled substance was put.

The researcher is responsible for the destruction of any unused or expired controlled substance. The destruction must be witnessed by a member of his/her research staff who is working on the same research project as specified in the exemption, and who works under the researcher’s direction and control. The method of destruction used must alter or denature the controlled substance in such a way as to make it non-recoverable and thus make their consumption improbable or impossible. The researcher is required to keep and retain for a period of two years from the date of the making of the record, the following information:

• the name, strength per unit, and quantity of any controlled substance to be destroyed;
• the date of destruction; and
• the reason for destruction.

Immediately following the destruction, the researcher and the witness are required to sign and print their names on a joint statement indicating that they witnessed the destruction and that the controlled substance destroyed has been altered or denatured to such an extent that its consumption has been rendered impossible or improbable.

The researcher shall make such records available to the Minister or an inspector upon request.


PHAC Biohazard Information

The Public Health Agency of Canada has implemented since December 2015, new regulations pertaining to the use of Human Pathogens and Toxins. Background information can be found on their website and details on the regulation here.

In order to work with Biohazardous Materials in a laboratory setting, researchers must complete an “Application to Use Biohazardous Materials”. These applications are reviewed and approved by McGill's Environmental Health and Safety Office (not the Animal Care Committee). Approval of the Application means that the researcher is compliant with the Biosafety Programwhich includes lab inspections and training.

Useful links (these two are also available as free Apps for a smart phone or tablet as well):


Small Animal Imaging Labs (SAIL)

PDF icon SAIL-SOP-01-Rodent Transportation Procedure

PDF icon SAIL-SOP-02-Animal Management and Housing at the SAIL Facility

PDF icon SAIL-SOP-03- Working with CL2 Animals

PDF icon SAIL-MRI-SOP-01-Pre-scan Procedures

PDF icon SAIL-MRI-SOP-02-Anesthesia Induction and Maintenance

PDF icon SAIL-MRI-SOP-03-In-Scan Subject Health Monitoring

PDF icon SAIL-MRI-SOP-04-Post-Scan Recovery and Follow-up

PDF icon SAIL-MRI-SOP-05-Cleaning and Decontamination

PDF icon SAIL-MRI-SOP-06-Daily Maintenance and Cleaning

PDF icon SAIL-MRI-SOP-07-Weekly Maintenance and Cleaning

PDF icon SAIL-PET-SOP-01-Radioligand Handling

PDF icon SAIL-PET-SOP-02-Animal and Scanner Preparation

PDF icon SAIL-PET-SOP-03-Anesthesia Induction and Maintenance

PDF icon SAIL-PET-SOP-04-Scanning and Monitoring

PDF icon SAIL-PET-SOP-05- Post-scan Recovery and Follow-up

PDF icon SAIL-PET-SOP-06-Cleaning and Decontamination

PDF icon SAIL-PET-SOP-08-Weekly Maintenance and Cleaning

PDF icon SAIL-PET-SOP-09-Radioactive Cages Management

PDF icon SAIL-Xtreme-SOP-01-Animal and Imager Preparation

PDF icon SAIL-Xtreme-SOP-02-Anesthesia Induction and Maintenance

PDF icon SAIL-Xtreme-SOP-03-Animal Recovery and Follow-up

PDF icon SAIL-Xtreme-SOP-04-Cleaning and Decontamination

PDF icon SAIL-Xtreme-SOP-05-Daily Maintenance and Cleaning