The labs of Dr John White and Dr Jorg Fritz are seeking for an highly motivated postdoctoral fellow, who can begin in May or June 2018. The postdoc should have expertise in flow cytometry and mouse work, and competence in Bioinformatics would be an asset. The successful candidate will work in both lab environments.
2017
-Dimitrov V, White JH., Vitamin D signaling in intestinal innate immunity and homeostasis., Mol Cell Endocrinol. 2017 Sep 15
-Iu M, Zago M, Rico de Souza A, Bouttier M, Pareek S, White JH, Hamid Q, Eidelman DH, Baglole CJ., RelB attenuates cigarette smoke extract-induced apoptosis in association with transcriptional regulation of the aryl hydrocarbon receptor., Free Radic Biol Med. 2017 Jul;
2016
- White JH., Vitamin D deficiency and the pathogenesis of Crohn's disease., J Steroid Biochem Mol Biol. 2016 Dec 23. Review.
- Bouttier M, Laperriere D, Memari B, Mangiapane J, Fiore A, Mitchell E, Verway M, Behr MA, Sladek R, Barreiro LB, Mader S, White JH., Alu repeats as transcriptional regulatory platforms in macrophage responses to M. tuberculosis infection., Nucleic Acids Res. 2016 Dec 15;
- Boukhaled GM, Cordeiro B, Deblois G, Dimitrov V, Bailey SD, Holowka T, Domi A, Guak H, Chiu HH, Everts B, Pearce EJ, Lupien M, White JH, Krawczyk CM., The Transcriptional Repressor Polycomb Group Factor 6, PCGF6, Negatively Regulates Dendritic Cell Activation and Promotes Quiescence., Cell Rep. 2016 Aug 16;
- Jensen ME, Mailhot G, Alos N, Rousseau E, White JH, Khamessan A, Ducharme FM, Vitamin D intervention in preschoolers with viral-induced asthma (DIVA): a pilot randomised controlled trial. Trials. 2016 Jul 26
- Dimitrov V, White JH., Calcium, vitamin D, and immunity in the colon., Am J Clin Nutr. 2016 May;103(5):1195-6. doi: 10.3945/ajcn.116.134247.
2015
- Memari B, Bouttier M, Dimitrov V, Ouellette M, Behr MA, Fritz JH, White JH. Engagement of the Aryl Hydrocarbon Receptor in Mycobacterium tuberculosis-Infected Macrophages Has Pleiotropic Effects on Innate Immune Signaling. J Immunol. 2015 Nov 1
- Dimitrov V, White JH. Species-specific regulation of innate immunity by vitamin D signaling. J Steroid Biochem Mol Biol. 2015 Sep. Review.
- Fekrmandi F, Wang TT, White JH. The hormone-bound vitamin D receptor enhances the FBW7-dependent turnover of NF-κB subunits. Sci Rep. 2015 Aug 13;5:13002. doi: 10.1038/srep13002.
- Kaldre D, Wang TT, Fischer J, White JH, Gleason JL. Optimization of histone deacetylase inhibitor activity in non-secosteroidal vitamin D-receptor agonist hybrids. Bioorg Med Chem. 2015 Aug.
- White JH. JAK3 talks to renal 25-hydroxyvitamin D 1alpha-hydroxylase. Kidney Int. 87(4):678-9.
- Goltzman D, Hendy GN, White JH. Vitamin D and its receptor during late development. Biochim Biophys Acta. 1849(2):171-180.
2014
- Dimitrov V, Salehi-Tabar R, An BS, White JH. Non-classical mechanisms of transcriptional regulation by the vitamin D receptor: insights into calcium homeostasis, immune system regulation and cancer chemoprevention. J Steroid Biochem Mol Biol. 2014 Oct
- Calderon MR, Verway M, Benslama RO, Birlea M, Bouttier M, Dimitrov V, Mader S, White JH. Ligand-dependent corepressor contributes to transcriptional repression by C2H2 zinc-finger transcription factor ZBRK1 through association with KRAB-associated protein-1. Nucleic Acids Res. 42(11):7012-27
2013
- White JH. Vitamin D and human health: more than just bone. Nat Rev Endocrinol. 9(10):623
- Dimitrov V, Salehi-Tabar R, An BS, White JH. Non-classical mechanisms of transcriptional regulation by the vitamin D receptor: Insights into calcium homeostasis, immune system regulation and cancer chemoprevention. J Steroid Biochem Mol Biol. 109, 18827-18832
- Verway, M., Bouttier, M., Wang, T.T., Carrier, M., Calderon, M., An, B.-S., Devemy, E., McIntosh, F., Divangahi, M., Behr, M.A. and White, J.H. Vitamin D induces interleukin-1b expression: Paracrine macrophage-epithelial signaling controls M. tuberculosis infection. PLoS Pathogens 9 (6): e1003407. doi: 10.1371/journal.ppat.1003407
2012
Salehi-Tabar, R., Nguyen-Yamamoto, L., Tavera-Mendoza, L.E., Quail, T., Dimitrov, V., An, B.-S., Glass, L., Goltzman, D. and White, J.H. The vitamin D receptor as a master regulator of the cMYC/MXD1 network. Proc. Nat. Acad. Sci. U.S.A. 109, 18827-32.
Voted one of the top 10 cancer research stories of 2012 by the Canadian Cancer Society.
Fisher, J., Wang, T.T., Kaldre, D., Rochel, N., Moras, D., White, J.H., Gleason J.L. Synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition. Chemistry & Biology 19, 963-71.
2010
An, B.-S., Tavera-Mendoza, L.E., Dimitrov, V., Wang, X., Calderon, M., Wang, H.-J., and White, J.H. Stimulation of SIRT1-regulated FoxO protein function by the ligand-bound vitamin D receptor. Mol. Cell. Biol. 30, 4890-4900.
Wang, T.T, Dabbas, B., Laperriere, D., Bitton, A., Tavera-Mendoza, L.E., Soualhine, H., Dionne, S., Servant, M.J., Bitton, A., Seidman, E., Mader, S., Behr, M. and White, J.H. Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-beta defensin 2 innate immune pathway defective in Crohn’s disease. J. Biol. Chem. 285, 2227 – 2231.
Recommended twice by the Faculty of 1000; Featured in ‘Montréal en santé’ magazine, Fall 2010.
2003-2009
Palijan, A., Fernandes, I., Verway, M., Kourelis, M., Bastien, Y., Tang, L., Tavera-Mendoza, L.E., Li, Z., Bertos, N.R., Bourdeau, V., Mader, S., Yang, X.J. and White, J.H. (2009) Function of HDAC6 as a cofactor of nuclear receptor corepressor LCoR. J. Biol. Chem. 284, 30264-74.
Tavera-Mendoza, L.E., Quach, T., Dabbas, B., Hudon, J., Liao, X., Palijan, A., Gleason, J.L., and White, J.H. (2008) Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist. Proc. Nat. Acad. Sci. U.S.A. 105, 8250-55.
Tavera-Mendoza LE, White JH. (2007) Cell defenses and the sunshine vitamin. Sci Am. 297(5):62-5, 68-70, 72.
Tavera-Mendoza, L., Wang, T.T., Lallemant, B., Zhang, R., Nagai, Y., Bourdeau, V., Ramiro Calderon, M., Desbarats, J., Mader, S., and White, J.H. (2006) Convergence of vitamin D and retinoic acid signaling at a common hormone response element. EMBO Rep. 7, 180-185.
Wang, T.T., Tavera-Mendoza, L., Laperriere, D., Nagai, Y., Burton MacLeod, N., Libby, E., Zhang, R., Bourdeau, V., Konstorum, A., Lallemant, B., Mader, S. and White, J.H. (2005) Large-scale in silico and microarray-based genomic screening of 1,25-dihydroxyvitamin D3 target genes. Mol. Endocrinol. 19, 2685-95.
Wang, T.T., Nestel, F., Bourdeau, V., Nagai, Y., Wang, Q., Wu, J., Tavera-Mendoza, L., Lin, R., Hanrahan, J.H., Mader, S. and White, J.H. 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J. Immunol. (Cutting Edge Report). 173, 2909-12.
Bourdeau, V., Deschenes, J., Metivier, R., Nagai, Y., Nguyen, D., Bretschneider, N., Gannon, F., White, J.H. and Mader S. (2004) Genome-wide identification of high affinity estrogen response elements in human and mouse. Mol. Endocrinol. 18, 1411-1427.
Fernandes, I, Bastien, Y., Wai, T., Nygard, K., Lin, R., Cormier, O., Lee, H.S., Eng, F., Bertos, N.R., Pelletier, N., Mader, S., Han V.K.M., Yang, X.J. and White, J.H. (2003) Ligand-dependent corepressor LCoR functions by histone deacetylase-dependent and –independent mechanisms. Molecular Cell, 11, 139-50.
Iu M, Zago M, Rico de Souza A, Bouttier M, Pareek S, White JH, Hamid Q, Eidelman DH, Baglole CJ.
Free Radic Biol Med. 2017 Jul;108:19-31. doi: 10.1016/j.freeradbiomed.2017.02.045. Epub 2017 Feb 27.