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Brian M. Gilfix, MDCM, Ph.D.
Associate Professor, Department of Medicine Program Director For Residency training in Medical Biochemistry Room E04.1614, 1001 Decarie Blvd., Montreal, QC H4A 3J1 Tel: 514-934-1934 ext. 34410 brian.gilfix [at] mcgill.ca |
Biographical Sketch
BSc (Honours) in Microbiology, U. of Manitoba1975; PhD in Biochemistry, U. of Western Ontario 1982; MDCM, McGill U. 1988; Specialty Training in Medical Biochemistry, McGill U, 1993.
Keywords
Molecular diagnostics, HPLC, homocysteine, cysteine, alpha1-antitrypsin, porphyria
Research or Clinical Activities
My research activities are centered on the development of analytical techniques in HPLC and molecular diagnostics. My clinical activities are centered on selected inherited disorders (homocystinuria, porphyria, alpha1-antitrypsin deficiency, lipid disorders).
Selected Recent Publications
Bidla G, Watkins D, Chéry C, Froese DS, Ells C, Karachian M, Saskin A, Christensen KE, Gilfix BM, Guéant JL, Rosenblatt DS. Biochemical analysis of patients with mutations in MTHFD1 and a diagnosis of methylenetetrahydrofolate dehydrogenase 1 deficiency. Mol Genet Metab 2020;130:179-182. PMID: 32414565
Mattman A, Gilfix BM, Chen SX, DeMarco ML, Kyle BD, Parker ML, Agbor TA, Jung B, Selvarajah S, Barakauskas VE, Vaags AK, Estey MP, Nelson TN, Speevak MD. Alpha-1-antitrypsin molecular testing in Canada: A seven year, multi-centre comparison. Clinical Biochemistry. 2020 Jul 8; 81:27-33. PMID: 32387440
Bidla G, Rosenblatt D, Gilfix BM. Identification of Variants in Alpha-1-Antitrypsin by High Resolution Melting. J Applied Laboratory Medicine. 2021 Apr 29; 16(3):716-7287:jfaa191. PMID: 33331634
Therrien C, Bélanger-Collard M, Skrzypczak J, Shank DK, Renaud C, Girouard J, Loungnarath V,Carrier M, Brochu G, Tourangeau F, Gilfix B, Piche A, Bazin R, Guérin R, Lavoie M, Martel-Laferrière V, Fortin C, Benoit A, Marcoux D, Gauthier N, Laumaea AM, Gasser R Finzi A, Roger M. Multicenter Evaluation of the Clinical Performance and the Neutralizing Antibody Activity Prediction. Properties of ten high throughput serological assays used in Clinical Laboratories. J Clin Microbiol 2020 Feb 18; 59(3): e02511-20. PMID: 33303562
Sorin M, Watkins D, Gilfix BM, Rosenblatt DS. Methionine Dependence in Tumor Cells: The potential role of Cobalamin and MMACHC. Molecular Genetics and Metabolism 2021 Mar;132:151-161. PMID: 33487542