Svetlana V. Komarova

Biographical Sketch

Dr. Svetlana V. Komarova is an Associate Professor, McGill University and a Research Scientist at the Shriners Hospital for Children-Canada. She completed her undergraduate education in physics at the Moscow State University, Russia, and obtained a doctorate in biophysics from the Institute of Theoretical and Experimental Biophysics, Pushchino, Russia. She received postdoctoral training at NASA Ames Research Center, the University of Cincinnati and the University of Western Ontario.

Keywords

Osteoclast; osteoblast; bone microenvironment; metabolism, mathematical modeling

Research or Clinical Activities

Dr. Komarova’s research interests are in bone-centered physiology. She uses in vitro, in vivo and in silico approaches to understand how mechanical, biochemical, and cellular microenvironment shapes the function of bone cells; and how the function of bone cells in turn alters micro- and macro-environment of the organism. Her laboratory members use live cell imaging, cell and molecular biology as well as in vivo approaches to study cell-cell and cell-matrix interactions in the bone microenvironment, the role of mechanical forces in regulating bone cells, and the consequences of altered bone resorption for the whole body physiology. In addition, she aims to develop computational support for the projects, including quantitative literature reviews, mathematical models to help in understanding the complex interactions, and computational tools for data analysis.

Selected Recent Publications

McKee TJ, Komarova SV (2017) Is it time to reinvent basic cell culture medium? Am J Physiol Cell Physiol. [Epub ahead of print]

Steer K, Stavnichuk M, Morris M, Komarova SV (2016) Bone health in patients with hematopoietic disorders of bone marrow origin: systematic review and meta- analysis. J Bone Miner Res. 2016 [Epub ahead of print]

Xing S, Grol MW, Grutter PH, Dixon SJ, Komarova SV. (2016) Modeling interactions among individual P2 receptors to explain complex response patterns over a wide range of ATP concentrations. Front Physiol. 7:294.

Abdelaziz DM, Abdullah S, Magnussen C, Ribeiro-da-Silva A, Komarova SV, Rauch F, Stone LS.(2015) Behavioral signs of pain and functional impairment in a mouse model of osteogenesis imperfecta. Bone. 81:400-6.

Rafiei S, Tiedemann K, Tabariès S, Siegel PM, Komarova SV (2015) Peroxiredoxin 4: a novel secreted mediator of cancer induced osteoclastogenesis. Cancer Lett. 361(2):262-70. 

PubMed Publications – S. Komarova