 |
Cynthia Gates Gooyer, Ph.D. Associate Professor, Departments of Pediatrics and Experimental Medicine Block E, 1001 Decarie Boulevard Office: EM0.2248 (514-934-1934 x22481) cynthia.goodyer [at] mcgill.ca
|
Biographical Sketch
I am co-PI on a CIHR-funded Team Grant that is focused on investigating and decreasing our exposure to three families of endocrine-disrupting chemicals (EDCs) in food, drinking water and breast milk: flame retardants, bisphenols and phthalates. This is a multidisciplinary research team of 25 members from multiple centres in Canada, South Africa, the USA and Europe. These EDCs are environmental contaminants that pose a potential health risk not only to individuals but also to future generations around the world.
A second focus of my research is on human growth. The long-term goal of this CIHR-funded program is to to define genetic alterations in children with abnormal growth or with metabolic disorders, including obesity and cancer. We are presently working on identifying regions within the growth hormone receptor gene that control expression of the receptor in major growth hormone target tissues such as bone, liver, muscle and fat.
Keywords
Endocrine disrupting chemicals, EDCs, brominated flame retardants, organophosphate flame retardants, bisphenols, phthalates, human growth, growth hormone receptor, idiopathic short stature, obesity, cancer.
Research or Clinical Activities
Please see Biographical Sketch
Selected Recent Publications
Rawn, D.F.K., Gaertner, D.W., Weber, D., Curran, I.H.A., Cooke G.M. and Goodyer, C.G. Hexabromocyclododecane concentrations in Canadian human fetal liver and placental tissues. Science of the Total Environment 468-9C: 622-629, 2014.
Elzein, S.* and Goodyer, C.G. Regulation of human growth hormone receptor expression by microRNAs. Mol Endocrinol 28: 1448-1459, 2014.
Poon, S., Wade, M.W., Aleksa, K., Rawn, D.F.K., Carnevale, A., Gaertner, D.W., Sadler, A., Breton, F., Koren, G., Ernest, S.R., Lalancette, C, Robaire, B., Hales, B.F. and Goodyer, C.G. Hair as a biomarker of exposure to polybrominated diphenyl ethers (PBDEs). Environ Sci Technol 48: 14650-14658, 2014.
Lefèvre, P.L.C., Wade, M., Goodyer, C.G., Hales, B.F. and Robaire, B. A mixture reflecting polybrominated diphenyl ether (PBDE) profiles detected in human follicular fluid significantly affects steroidogenesis and induces oxidative stress in a female human granulosa cell line. Endocrinology 157: 2698-2711, 2016.
Goodyer, C.G., Poon, S., Aleksa, K., Hou, L., Atehortua, V., Carnevale, A., Jednak, R., Emil, S., Bagli, D., Dave, S., Hales B.F. and Chevrier, J. A case-control study of maternal polybrominated diphenyl ether (PBDE) exposure and cryptorchidism in Canadian populations. Environmental Health Perspectives 125: 057004, 2017.
Dias, C.*, Giordano, M., Frechette, R., Bellone, S., Polychronakos, C., Legault, L., Deal, C.L. and Goodyer, C.G. Genetic variations at the human Growth Hormone Receptor (GHR) gene locus are associated with idiopathic short stature (ISS). Journal of Cellular and Molecular Medicine 21(11): 2985-2999, 2017.